Now showing items 14490-14509 of 41729
Calle Fabregat, Carlos de la (Date of defense: 2022-03-15)
OBJECTIVE: Identifying predictive biomarkers at early stages of undifferentiated arthritis (UA) is crucial for starting appropriate therapies to avoid poor outcomes. Monocytes and macrophages, largely associated with ...
Iglesia Rodríguez, Alberto de la (Date of defense: 2022-10-28)
[eng] Contrasting the traditional idea of the male gamete being a simple carrier of the paternal DNA, evidence in the last decades revealed that the sperm cell provides the embryo with different layers of epigenetic ...
Reis, Kadri (Date of defense: 2016-03-23)
Una gran proporción del genoma de la mayoría de eucariotas superiores está formado por secuencias repetitivas de DNA que contienen señales de represión de la transcripción. Para entender mejor cómo funciona la herencia ...
Custodio Rojo, Joaquín (Date of defense: 2014-10-15)
Mitjançant tècniques d’anàlisi de tot el genoma hem sigut capaços d'identificar regions diferencialment metilades entre teixit de colon normal i tumoral provinents del mateix pacient. Un dels gens més importants és AKR1B1, ...
Vento Tormo, Roser (Date of defense: 2016-01-22)
En aquesta tesi s’han estudiat els mecanismes epigenètics implicats en diferents processos d’inflamació i diferenciació a partir de monòcits (MO). És possible recapitular la diferenciació terminal de MO a cèl·lules ...
Rodríguez Cortez, Virginia Carolina (Date of defense: 2015-02-06)
The proper function of the immune system requires complex regulatory mechanisms and a highly strict balance in the amount and function of immune and non-immune elements. Part of the primary immunodeficiencies result from ...
Oliveira Mateos, Cristina (Date of defense: 2020-06-16)
The vast majority of the human genome is transcribed giving rise to non-coding RNAs. Antisense transcripts are one of the most abundant types of long non-coding RNAs and many of them have regulatory roles in the transcription ...
Ortiz Barahona, Vanessa (Date of defense: 2022-04-01)
The general aim of this thesis is to identify and characterize if there are DNA methylation patterns giving rise to cancer-related m5C RNA modification defects, potentially promoting malignant transformation and tumor ...
Crowley, Valerie Margarita (Date of defense: 2011-11-02)
Clonally variant gene expression (CVGE) is a common survival strategy used by many pathogens, including the malaria parasite Plasmodium falciparum. Among the genes that show CVGE are several members of the clag and eba ...
Pérez Salvia, Montserrat (Date of defense: 2019-03-01)
Cancer is considered nowadays a genetic and epigenetic disease. Aberrancies in epigenetic marks in DNA and histone tails together with alterations in epigenetic regulators responsible of catalyzing these marks have been ...
Borsari, Beatrice (Date of defense: 2021-03-26)
We have monitored the transcriptome and the epigenome of human pre-B cells transdifferentiating into macrophages. Analysis of these data provides a general framework to understand the relationship between gene expression ...
Rosselló Tortella, Margalida (Date of defense: 2021-12-09)
Transfer RNAs (tRNAs) are essential molecules that allow the translation of the genetic code into amino acids. Extensive research during the last 50 years have revealed that, despite their apparently simple structure and ...
Jubierre Zapater, Luz (Date of defense: 2017-10-09)
El Neuroblastoma (NB) es un cáncer derivado del sistema nervioso simpático, y es el tumor sólido más común en los niños de cero a dos años. Los NB son muy heterogéneos, tienen un curso clínico que puede variar desde la ...
Agirre Ortiz de Guzmán, Eneritz (Date of defense: 2013-06-21)
Generalment s'ha pensat que la regulació de l'splicing alternatiu està controlada principalment per la interacció entre els factors reguladors de l'splicing i la taxa d'elongació de la ARN polimerasa II (RNAPII). Hi ha ...
Fusté i Domínguez, Ester (Date of defense: 2012-11-19)
Resistance to antimicrobials is a well-known phenomenon leading to difficulties in the treatment of infectious diseases. The genetic determinants of such resistance are in general well understood: plasmids, transposons, ...
Morante Palacios, Octavio (Date of defense: 2022-06-02)
[eng] Monocytes are highly plastic cells and possess the ability to differentiate into cell types with very different immunological properties. Depending on the external stimuli and the specific immune context, they can ...
Ginestí Rosell, Anna (Date of defense: 2006-12-15)
Aquesta tesis doctoral persegueix un doble objectiu. En primer lloc, aportar un corpus tan complet com sigui possible de les inscripcions funeràries ateneses dedicades a estrangers i datades entre els segles VI i IV aC. ...
Carbonell i Manils, Joan (Date of defense: 1991-10-01)
Llasat Botija, Carme (Date of defense: 1987-05-24)
Se han estudiado los factores meteorológicos asociados a seis inundaciones catastróficas acaecidas en Cataluña. Previamente al análisis de tales episodios se ha recopilado toda la información disponible sobre el tema, ...
Martínez Carrasco, Robert (Date of defense: 2017-12-21)
La tesi doctoral que ací es presenta planteja, mitjançant una metodologia de caire quantitativo-qualitativa, una visió en conjunt de la didàctica de la traducció jurídica en Espanya, amb èmfasi en la pedagogia de l’aula i ...