Browsing by Title

Involvement of pre-proenkephalin and sigma-1 receptors in nicotine addiction

Kummer, Sami (Date of defense: 2020-09-29)

El tabaquismo es la principal causa de muerte evitable en todo el mundo, responsable de más de 7 millones de muertes al año. La nicotina es el principal componente psicoactivo del tabaco y la responsable de sus propiedades ...

Involvement of the cerebellum in cocaine-induced memory

Carbo Gas, María (Date of defense: 2017-06-28)

Because of its role in drug-seeking, consumption and addictive behavior, there is a growing interest in identifying the neural circuits and molecular mechanisms underlying the formation, maintenance and retrieval of ...

Involvement of the endocannabinoid system in osteoarthritis pain

La Porta, Carmen (Date of defense: 2015-10-15)

Chronic pain is a major clinical problem producing huge economic and social burdens. Currently, chronic pain treatment has limited efficacy and significant side effects. One of the reasons of this unmet clinical need is ...

Involvement of the endogenous opioid and cannabinoid systems in addictive like-behaviours

Mancino, Samantha (Date of defense: 2016-01-22)

The increase incidence of obesity and eating disorders represents a major health problem in developed countries. The low rate of success of treatments to prevent or reverse obesity, and overeating that causes it, highlights ...

Involvement of the hypocretin/orexin system in the addictive properties of nicotine

Plaza-Zabala, Ainhoa (Date of defense: 2012-11-26)

Hypocretin-1 and hypocretin-2, also known as orexin-A and orexin-B, are 2 neuropeptides that are exclusively expressed by a small subset of neurons of the lateral hypothalamic area. Despite their restricted expression ...

Involvement of the Microtubule-Regulated RhoGEF GEF-H1 in the G12 family signaling pathways

Garrido Antequera, Georgina (Date of defense: 2014-09-16)

Heterotrimeric G proteins are masters regulators of cell homeostasis. They coordinate the signaling between G protein coupled receptors (GPCRs) and their intracellular effectors. Heterotrimeric G proteins are composed of ...

Involvement of the prefrontal cortex-limbic pathway in the development of food addiction

Calvé Pérez, Pablo (Date of defense: 2022-07-04)

Food addiction is closely associated with eating disorders including obesity and binge eating. However, the neural alterations underlying this disorder have not been yet clarified. We have trained mice in an operant model ...

Ion beam synthesis of silicon-carbon structures and related materials

Calvo Barrio, Lorenzo (Date of defense: 1999-07-16)

The goal of this dissertation is the study and characterisation of high dose Carbon (C) implantation processes into Silicon (Si) and related materials for the synthesis of Silicon Carbide (SiC). The attainment of ...

Ion binding landscapes and molecular dynamics of phospholipid membranes

Yang, Jing (Date of defense: 2015-12-11)

This thesis aims at studying the physical-chemical properties of model lipid bilayers in physiological environments. Since in such conditions biological membranes composed of phospholipids and cholesterol are surrounded ...

Ionic complexes of biodegradable polyelectrolytes

Tolentino Chivite, Ainhoa (Date of defense: 2014-04-29)

Biopolymers are polymers produced by living organisms. A more broad classification would embrace also those polymers synthesized from renewable sources which are able to display biodegradability. The demand of biopolymers ...

Ionic complexes of naturally-occurring biopolymers and cationic surfactants : a platform for industrial and biomedical applications

Gamarra Montes, Ana (Date of defense: 2018-07-13)

In recent years, the increasing public concern about the environmental pollution caused by persistent plastic wastes has stimulated the interest in replacing synthetic polymers by biopolymers. The term biopolymer refers ...

Ionic copolyesters and their nanocomposites: synthesis, characterization and properties

Bautista Betancur, Mayka Irina (Date of defense: 2015-09-21)

A polymer containing small amounts of ionic groups either along the polymer backbone chains or as pendant groups is defined as ionomer. As originally proposed by Eisenberg, the interaction between ionic groups leads to the ...

Ionic liquid-assisted the preparation of transparent cellulosic biocomposite films

Amini, Elahe (Date of defense: 2023-12-14)

(English) Interest in new environmentally friendly cellulose-based products has tremendously increased in recent years. Cellulose-based composites come in various forms and have potential applications in construction, ...

Ionic liquids with and without transition metal nanoparticles for advanced heat transfer fluids and catalysis applications.

Patil, Virendra Sudam (Date of defense: 2015-07-21)

Tecnologies de transferència de calor de nova generació, amb menys consum d'energia per al benestar de la societat són necessàries. En aquest sentit, els líquids iònics (ILS) són en l'actualitat els fluids més investigats ...

IoT@run-time: a model-based approach to support deployment and self-adaptations in IoT systems

Alfonso, Ivan (Date of defense: 2022-12-05)

Today, most Internet of Things (IoT) systems leverage edge and fog computing to meet increasingly restrictive requirements and improve quality of service (QoS). Although these multi-layer architectures can improve system ...

l'IPAD a l'àrea de música. Disseny, aplicació i anàlisi d'una propsota didàctica a l'educació primària

Ufartes Ollé, Gemma (Date of defense: 2016-01-29)

La tecnologia digital ha redibuixat la manera de conviure i d’entendre el món. S’ha instaurat en el dia a dia de la majoria de llars però, segons les darreres investigacions, l’escola tot just s’inicia en l’adopció de nous ...

iPSCs, CRISPR/Cas9 y protocolos de diferenciación basados en factores de transcripción para generar nuevos modelos neuronales y astrocíticos del síndrome de Sanfilippo

Benetó Gandia, Noelia (Date of defense: 2020-07-16)

El objetivo general de esta tesis doctoral ha sido la generación de nuevos modelos celulares para el síndrome de Sanfilippo y su utilización para ensayar una aproximación terapéutica para esta enfermedad basada en el uso ...