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Now showing items 27464-27483 of 41663
Mechanisms behind the oncogene-induced senescence (OIS) – oncogene-induced apoptosis (OIA) decision in cells expressing p95HER2
In response to oncogenic stresses cells activate two different tumor suppressor mechanisms: Oncogene-induced senescence (OIS), a terminal cell proliferation arrest, or oncogene-induced apoptosis (OIA), which leads to cell ...
Mechanisms controlling the selective iron and zinc biofortification of rice
L’arròs es un cultiu bàsic, consumit per mes de 3 billons de persones. Es una font pobra en ferro (Fe) i zinc (Zn) per la qual cosa les poblacions pobres que depenen de l’arros per a la seva supervivència, sofreixen d’anèmia ...
Mechanisms for service-oriented resource allocation in IoT
Albeit several IoT applications have been recently deployed in several fields, including environment and industry monitoring, Smart Home, Smart Hospital and Smart Agriculture, current deployments are mostly host-oriented, ...
Mechanisms involved in motor responses of the rat small intestine in healthy conditions and after Trichinella Spiralis infection
El objetivo de este estudio es evaluar los mecanismos neurales y musculares implicados en la contracción y la relajación del músculo longitudinal del intestino delgado de rata en condiciones control y tras la infestación ...
Mechanisms involved in the remyelinating effect of sildenafil
Multiple Sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system characterized by a coordinated inflammatory attack on the myelin sheaths with ensuing damage to the underlying axons. Using ...
Mechanisms of acquired resistance to anti-EGFR therapies in squamous cell carcinoma
Targeted therapies against the Epidermal Growth Factor Receptor (EGFR) are useful to treat many human cancers such as non-small cell lung cancer, colorectal cancer and head and neck cancer. However, the efficacy of such ...
Mechanisms of cytokine release induced by electronegative LDL in monocytes. The role of ceramide and the receptors CD14-TLR4
L’LDL electronegativa (LDL(-)) és una LDL modificada present en circulació amb propietats inflamatòries incloent la inducció de l’alliberament de citoquines en cèl·lules relacionades amb l’arteriosclerosi, tals com monòcits ...
Mechanisms of epigenetic regulation relevant to innate responses against pathogens
This doctoral thesis describes the participation of epigenetic mechanisms, and more specifically DNA methylation, in innate immune responses against pathogens. Innate immunity is the first barrier of defense against ...
Mechanisms of evolutionary innovation in mammalian genes
Actualment, degut a la disponibilitat d’un gran nombre de genomes seqüenciats, el camp de la genòmica comparativa està experimentant grans avenços. Ara són possibles una àmplia gama d’estudis que fins fa poc eren inimaginables. ...
Mechanisms of fluoroquinolone resistance in Escherichia coli, Salmonella Typhimurium and Yersinia enterocolitica. Influence on expression of virulence factors.
INTRODUCTION Quinolones are potent and broad spectrum antibacterial agents and, among them, several fluoroquinolones, such as ciprofloxacin, are the treatment of choice against several human infections. Resistance to ...
Mechanisms of invasion and metastasis in colorectal cancer
We studied the mechanisms driving the metastatic spread in colorectal cancer (CRC), focusing in the MAPK pathway. We developed in vivo a highly metastatic cell line using a KRAS-mutated cell line (SW620) in an ortothopic ...
Mechanisms of LXR-mediated control of obesity-induced metaflammation and insulin-resistance
Obesity is nowadays considered a pandemic disease, and its incidence correlates with the concomitant increase of a set of associated comorbidities, including T2D, cardiovascular diseases, fatty liver disease, among others, ...
Mechanisms of muscle wasting in cachexia models : therapeutic implications
La caquexia afecta negativamente a los pacientes con enfermedades crónicas y sobre todo en el cáncer. Las estrategias terapéuticas son aún limitadas. Los beta2-agonistas (formoterol) y el soporte nutricional (L-carnitina) ...
Mechanisms of Ni-Catalysed C–O Functionalisation and Carboxylation Reactions
Comprendre els mecanismes de les transformacions catalítiques és extremadament important, ja que permet als químics millorar les reaccions reduint, per exemple, la càrrega de catalitzadors, impedir la formació de subproductes ...
Mechanisms of proteolytic activity regulation exerted via a unique propeptide in matrix metalloproteinases and intra/intermolecular interactions in a novel family of minimal gluzincins
Metallopeptidases are major players in the physiology and pathology of all living organisms. Their exquisite regulation is therefore essential for proper function and to prevent misdirected temporal and/or spatial proteolytic ...
Mechanisms of resistance toT-DM1 in HER2-positive breast cancer
El cáncer de mama HER2-positivo representa alrededor del 15-30% del total de pacientes con cáncer de mama. Este subtipo tiene un mal pronóstico, seguido del subtipo Triple-negativo (TNBC), que lo tiene aún peor. Actualmente, ...
Mechanisms of restricted activation of the Torso receptor: from the eggshell to the embryo
The establishment of the embryonic axis in the Drosophila embryo relies on four maternal systems. Anterior and posterior axes rely on morphogens located at the poles that will generate a gradient of activity along the ...
Mechanisms of synaptotoxicity in Alzheimer's disease : Pre- and postsynaptic differences to amyloid beta-induced injury
The mechanisms by which amyloid beta (Aβ) causes synaptic dysfunction in Alzheimer’s disease (AD) remain elusive. Aβ is derived by sequential cleavage of the amyloid precursor protein (APP) and released from neurons, but ...
Mechanisms regulating CXCR4 intracellular traffic and polarization in human hepatocellular carcinoma cells: cross-talk with the TGF-β pathway
CXCR4 is a chemokine receptor originally discovered and cloned in leukocytes that functions by controling the migration to the inflammatory foci. The CXCR4 chemokine receptor and its ligand, SDF-1α (also named CXCL12), are ...
Mechanisms responsible of sensory afferent projections into the hindbrain
Animals perceive the external world through their sensory systems, which consists in: i) sensory receptors that detect external stimuli; ii) neuronal pathways that convey the sensory information to the brain; and iii) ...
