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Now showing items 5726-5745 of 41700
Characterization of alternative therapeutic sites on the androgen receptor and novel protein-protein associations
The androgen receptor (AR) is a ligand-activated transcription factor that plays a crucial role in the correct development, differentiation, and function of male reproductive organs. Alterations in the AR protein or in the ...
Characterization of aluminum silicon/short carbon fiber composites fabricated by novel thixomixing method
The metal matrix composites (MMC) are widely used in different applications and offer high strength-to-weight ratio. In this thesis, it was developed a novel method to fabricate composite material in semi-solid state of ...
Characterization of amino acid changes in visual pigment evolution and interaction with associated proteins
Visual opsins are G protein-coupled receptors that function as light photoreceptors in the vertebrate retina. Rhodopsin is the visual pigment located in the rod photoreceptor cells specialized in scotopic vision. Bovine ...
Characterization of antimicrobial resistance and bacterial diversity in the gastrointestinal and respiratory tract of calves fed different types of milk
L’ús de la llet de rebuig procedent de vaques tractades amb antimicrobians en l’alimentació de vedells lactants és una pràctica habitual entre els ramaders. En aquesta tesi es van realitzar tres estudis per avaluar els ...
Characterization of atmospheric pollution dynamics in Spain by means of air quality modelling
Atmospheric pollution causes large impacts on human health and societal economic interests and it is a threat for the ecosystems and the climate of the Earth. Improving the understanding of pollution dynamics is necessary ...
Characterization of autism spectrum disorder caused by alterations in complex genomic regions : molecular and pathophysiological mechanisms
Autism Spectrum Disorder (ASD) is a group of neurodevelopmental disorders, the etiology of which is unknown in the majority of cases. Little is known about complex genomic regions containing part of the missing heritability. ...
Characterization of BEND3, a novel interactor of deubiquitanase USP21
La monoubiquitinación de la histona H2A cumple un rol esencial en la represión génica. Diversas enzimas desubiquitinantes (DUBs) han sido identificadas, que remueven específicamente la ubiquitina de H2A en distintos ...
Characterization of biomarkers of the generation and functionality of tolerogenic dendritic cells differentiated with vitamin D3
En els darrers anys s’ha produït un gran avenç en el desenvolupament de teràpies cel•lulars inductores de tolerància per al tractament de malalties autoimmunitàries tals com l’esclerosi múltiple (EM) i altres patologies ...
Characterization of capacitance soil moisture sensors for the automated scheduling of drip irrigation in orchards
La sostenibilitat econòmica i ambiental de l’agricultura en regadiu requereix la millora dels sistemes de reg. L’optimització del reg en una parcel·la requereix proporcionar la dosi adequada d’aigua al moment adequat per ...
Characterization of CB1-5-HT2A receptor heteromers in the olfactory neuroepithelium of cannabis users and schizophrenia patients: implications for clinical and cognitive alterations
De moment no s'ha traçat un vincle clar entre etiologia, fisiopatologia i processos biològics en l'esquizofrènia, i la seva relació amb símptomes conductuals o cognitius específics. No obstant això, tant el sistema ...
Characterization of cellular factors involved in HIV-1 pathogenesis with potential therapeutic implications in viral infections and cancer
El paper principal del sistema immunitari humà es eliminar cèl·lules que presenten antígens forans i patrons anormals. No obstant, aquest sistema pot fallar a eliminar les anomalies, conduint a l’establiment de patologies ...
Characterization of clinically relevant RNA alterations for personalized cancer medicine
The following thesis tries to answer the question of wheter RNA processing alterations are informative for the clinical management of cancer patients. For this, the work is focused on solve two main issues: the development ...
Characterization of Counterfactual Reasoning Deficits in Schizophrenia Patients and Non-Psychotic First-Degree Relatives in Comparison with Healthy Control Subjects
Schizophrenia is one of the most serious and complex psychiatric illnesses supposing a great negative impact on the life of the individuals who suffer from it. Cognitive impairment is a core feature of the illness and is ...
Characterization of cytomegalovirus-induced adaptive NK cells and the role of CD94/NKG2C receptor
Human cytomegalovirus (HCMV) infection induces a persistent reconfiguration of the NK cell compartment in some individuals, promoting the development of a mature NK cell subset, hallmarked by high expression levels of ...
Characterization of cytotoxic ribonucleases: from the internalization pathway to the importance of dimeric structures
En aquesta tesi s'ha caracteritzat la ruta d'internalització de l'onconasa, una RNasa citotòxica. Els resultats indiquen que l'onconasa entra a les cèl·lules per la via dependent de clatrina i del complex AP-2. Seguidament ...
Characterization of damage evolution on metallic components using ultrasonic non-destructive methods
When fatigue is considered, it is expected that structures and machinery eventually fail. Still, when this damage is unexpected, besides of the negative economic impact that it produces, life of people could be potentially ...
Characterization of Dental Pulp Pluripotent-like Stem Cells (DPPSC) and their mesodermal differentiation potential.
Dental pulp represents an easily accessible autologous source of adult stem cell populations. Among them, a population named dental pulp pluripotent-like stem cells (DPPSC) has been isolated from the dental pulp of human ...
Characterization of Designated Communities of Geospatial Legacy Information and Their Application in Appraisal and Digital Preservation Decisions: A Case Study
Institutions that recognize the value of digital geographic legacy data for future use develop the motivation to preserve the data for the long term. International standards on preservation, such as for an open archival ...
Characterization of dissolved organic matter in wastewater using liquid chromatography-high resolution mass spectrometry
Individual hazardous chemicals and substance mixtures with synergistic toxicity ef-fects occur in the dissolved organic matter (DOM) of wastewater and negatively im-pact human health. Yet a large number of chemicals and ...
Characterization of emerging novel human astrovirus: form bedside to bench
Novel human astrovirus (HAstV) are enteric virus belonging to the Astroviridae family and were discovered 10 years ago by high-throughput sequencing. They are divided in two different clades, the HAstV-MLB including 3 ...
