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Now showing items 5850-5869 of 41732
Chemical approaches to the study of the ceramide synthase activity
Sphingolipids (SLs) are one of the major classes of lipids in eukaryotes. In addition to being essential structural components of cell membranes, SLs also play capital roles as signalling molecules. Ceramides (Cer) are a ...
Chemical design and validation of Ca 2+ -releasing platforms to promote vascularization in tissue regeneration
An insufficient vascularization of the wound site is often the cause of failure in tissue regeneration. The use of cell therapy or growth factors has introduced promising results, nevertheless, they are risky, expensive ...
Chemical Modulation of Identified Hit Compounds as Apoptosis Inhibitors
L’apoptosi és un procés biològic rellevant en moltes malalties. Un punt de regulació d’aquest procés és la formació d’un complex multiproteic anomenat apoptosoma; per tant, aquest complex té un gran interès per al ...
Chemical modulation of the nociceptive receptor TRPV1: Synthetic, biological and computational studies
El canal iònic Receptor Vanil·loide Tipus 1 (sigles en anglès TRPV1) es considera un important integrador de diverses senyals de dolor. D'entre tots els productes que interaccionen amb TRPV1, aquells que bloquegen el senyal ...
Chemical speciation on urinary lithiasis. Image analysis and separation techniques for the study of lithogenesis
La formació de concrecions sòlides al tracte urinari, malaltia que rep el nom de litiasi urinària, és un desordre molt comú arreu del món. La seva taxa de incidència és del 12% a la població mundial, i la de recurrència ...
Chemical tools for the study of sphingolipid metabolism in diseases
[eng] The main goals of this PhD thesis are closely related within the field of CDases and their key role in the regulation of sphingolipid metabolism. Thus, the roles of ACER3 and AC in different human diseases are of ...
Chemical tools to investigate the role of sphingolipids in disease
Sphingolipids (SLs) encompass a large and diverse family of lipids that are essential constituents of cellular membranes. In addition to their structural functions, SLs are also emerging as important signalling molecules ...
Chemical vapor deposition of hexagonal boron nitride and its use in electronic devices
Dielectrics are insulating materials used in many different electronic devices (e.g. capacitors, transistors, barristors), and play an important role in all of them. In fact, the dielectric is probably the most critical ...
Chemically synthesized peptide libraries as a new source of BBB-shuttles. Use of Mass Spectrometry for peptide identification and quantification
The blood-brain barrier (888) is a biological barrier that plays a crucial role protecting the brain from neurotoxic agents and regulating the influx and efflux of molecules required for the correct function of this organ. ...
Chemistry of dawsonites and application in catalysis
La dawsonita es un mineral cristalino hallado generalmente en la naturaleza en forma de hidróxicarbonato de sodio y aluminio, NaAlCO3(OH)2. Además del mineral, se han sintetizado diferentes tipos de dawsonitas variando su ...
Chemoenzymatic Synthesis of Carbohydrates and Derivatives with Engineered D-Fructose-6-Phosphate Aldolase
Biocatalysis is the chemical transformation of organic substrates by enzymes. This is the driving force of some of the oldest transformations known to humans. Nowadays, methods involving biocatalysts are gaining importance ...
Chemoenzymatic synthesis of sugar-related polyhydroxylated compounds, iminocyclitols and their derivatives as glycosidase inhibitors
Section 1 (Introduction) is a comprehensive review of the subjects discussed in this thesis: biocatalysis, aldolases and iminocyclitols. It contains a description of the application of dihydroxyacetone phosphate (DHAP) and ...
Chemoisosterism and its impact on drug polypharmacology
In medicinal chemistry, two chemical fragments are considered bioisosteric if they bind to the same protein environment. Accordingly, looking at the same players from an opposite perspective, two protein environments can ...
Chemomagnetooptically controlled nanomotors for (bio)contaminant removal in water
El objetivo de la tesis es desarrollar nanomotores autónomos de silicio/metal activados fotoelectroquímicamente, explorar y comprender los mecanismos involucrados en el proceso de propulsión y analizar su posible aplicación ...
Chemometric methods to process online spectrometry for quality monitoring of different water matrices
Water quality monitoring during the purification and sanitation processes in Drinking Water Treatment Plants (DWTP), Wastewater Treatment Plants (WWTP) and Water Reclamation Plants (ERA) is a necessary step to obtain a ...
Chern degree functions and Prym semicanonical pencils
Abelian varieties are projective algebraic varieties endowed with a group structure. They constitute one of the most explored objects in Algebraic Geometry throughout the last decades. On the one hand, abelian varieties ...
Chester A. Phillips and the forgotten history of bank credit
This thesis studies the main contributions to monetary theory by Chester A. Phillips in the 1920s and 1930s which deal with the expansion of the money supply when commercial banks use the creation of bank credit to purchase ...
Chicas y poder en la escuela. Identidades académicas, sociales y de género entre jóvenes de la periferia
El aparente mayor éxito escolar de las jóvenes en la mayoría de niveles educativos enmascara la permanencia de dificultades y de exclusiones que todavía viven las chicas a su paso por la escuela. Así mismo, la juventud ...
Child and Adult Non-Native Subject Development: A Bi-directional Study of English and Spanish as L2s
Aquesta tesi explora l'adquisició no-nativa de les propietats del subjecte gramatical en l'anglès i el castellà de nens i adults castellanoparlants i angloparlants, els quals no resideixen en el país de la L2, i contribueix ...
