Departament de Química Orgànica: Recent submissions
Now showing items 21-40 of 143
From phage display and venoms to protease-resistant peptides: Design of BBB-shuttles and peptides targeting EGF
Peptides play a critical role in human physiology and harbour a huge potential as therapeutic agents. In this thesis, new peptides have been discovered as ligands for the epidermal growth factor (EGF) and as new BBB-shuttles, ...
Péptidos sintéticos del GB virus C. Aplicación en el diagnóstico de infección y en el diseño de potenciales agentes terapéuticos contra el VIH-1
El GB virus C (GBV-C), también conocido como virus de la hepatitis G, es un virus humano no patogénico. Su infección es bastante frecuente, encontrándose incluso en personas sanas. Su prevalencia es mucho mayor en individuos ...
Design, synthesis and biophysical evaluation of peptides targeting pharmacologically relevant proteins
Protein-protein interactions (PPIs) and protein surfaces are considered challenging targets for drug discovery. In this field, conventional medicinal chemistry (i.e. small molecules) has largely failed to provide effective ...
Mayotlide: synthetic approaches and structural elucidation
Mayotlide is a marine peptide isolated by PharmaMar S.A. from Spongia sp.. The sequence of the aminoacids were achieved by MS-MS spectrometry, where two of them were tryptophans. The NMR spectroscopy revealed the presence ...
Universal diagnostic platforms based on oligonucleotide codified nanoparticles and DNA microarray devices
La medicina personalitzada esta prenent rellevància últimament. Aquesta es basa en la monitorització simultània de diferents biomarcadors, els biomarcadors poden ser molècules de diferent naturalesa química. Aquest fet fa ...
Synthesis of biaryl bicyclic peptides for recognition of protein surfaces
The present thesis is based on the development and optimization of a solid-phase strategy to prepare biaryl bicyclic pentapeptides. Suzuki-Miyaura cross-coupling reactions were used to obtain the biaryl bridge. The metholodogy ...
Blood-Brain Barrier Shuttles: From Design to Application
The work of this thesis is based on research on peptides able to cross the blood-brain barrier and their use as tools to enable the delivery of drugs into the brain. The blood-brain barrier (BBB) is a permeable but ...
Cyclic peptides and small proteins in molecular recognition
The present thesis is based on the work developed about the use of peptides and small proteins in protein surface molecular recognition. Peptides present several advantages when compared with small molecules and biologics: ...
Linkers for bioconjugation
Cancer is a heterogeneous disease that represents one of the principal causes of mortality in developed countries. Due to the social and economic implications of this pathology, tremendous efforts have been making over the ...
New strategies based on nanosystems to facilitate the crossing through biological barriers
During the past years working in Ernest Giralt’s group, I’ve been involved in three different subprojects that constitute one of the three chapter of my thesis and have the same common link: the use of peptides combined ...
Design, synthesis and characterisation of photoswitchable allosteric modulators of metabotropic glutamate receptors
Metabotropic glutamate receptors (mGlu receptors) are class C GPCRs widely distributed through the CNS and considered pharmacological targets for neurologic disorders, such as neuropathic pain and Parkinson’s disease, ...
Síntesi de l'amfidinolida E
La síntesi total de l’amfidinolida E ha estat l’objecte de la present Tesi. Aquest compost és un macròlid citotòxica aïllat per Kobayashi i col·laboradors del mar d’Okinawa (Japó). La retrosíntesi plantejada desconnecta ...
Multifunctional self-stratified polyurethane-polyurea nanosystems for smart drug delivery
This thesis, entitled "Multifunctional Self-stratified Polyurethane-Polyurea Nanosystems for Smart Drug Delivery" is structured as a compendium of publications, being organized around a methodological synthetic patent and ...
Noves aproximacions per a la detecció de microorganismes patògens
Aquesta tesi s'ha focalitzat en el desenvolupament de noves eines immunoquímiques per al diagnòstic de malalties infeccioses amb l'objectiu d'incrementar l'eficiència dels actuals mètodes de diagnòstic. Concretament, aquesta ...
Aproximació a la síntesi de la fluvirucina B₂
En el present treball de Tesi Doctoral s’ha desenvolupat una ruta sintètica per a l’obtenció de la fluvirucina B2 o Sch 38518. Realitzant petits canvis en cadascuna de les rutes convergents que la constitueixen, el fragment ...
Intermolecular Pauson-Khad reaction: study of the regioselectivity, photochemistry of the adducts and synthetic applications
The Pauson-Khand reaction (PKR), introduced by Pauson and Khand in 1973, is an efficient method to access the synthesis of five-membered rings in one single step. This reaction is a transition metal-mediated [2+2+1] ...
Tautomería de valencia en moléculas con número par de electrones: transición térmica al estado electrónico triplete inducida por un cambio conformacional. Nuevos materiales con comportamientos ferromagnéticos
Se han sintetizado una nueva familia de moléculas, puramente orgánicas y con número par de electrones, que presentan propiedades paramagnéticas. El trabajo de esta tesis ha consistido en conocer el fundamento por el cual ...
A Multiplexed diagnostic approach for cardiovascular disease biomarkers
In the course of this thesis, the optimal epitopes for the subsequent polyclonal rabbit antibody production for cTnI and NT-proBNP have been studied and chosen. cTnI and NT-proBNP are the most relevant cardio-specific ...
Síntesis de derivados del biciclo (4,3,0) nonano-7-espiro-ciclohexano
La (+)-pulegona, I, reducida con sodio y éter-agua da, además de mentoles, productos de condensación, siendo uno de ellos un reductodímero de fórmula C(20)H(36)O(2) con los dos oxígenos en forma de hidroxilo. La oxidación ...
Funcionalització de superfícies amb lligands per a la seva interacció específica amb avidina i estreptavidina
Se ha estudiado espectroscópicamente (UV-Vis, Raman, RMN) los equilibrios tautoméricos del ácido 2-(4'-hidroxifenilazo)benzoico (HABA) y el ácido 2-(4'-hidroxi-3',5'- dimetilfenilazo)benzoico. Estos equilibrios están ...
