Actividad anti-inflamatoria e inmunomoduladora de los inhibidores solubles del complemento C4BP ß- y factor H 

    Cárdenas Brito, Sonia Janneth (Date of defense: 2016-10-26)

    El sistema de complemento es parte fundamental de la inmunidad innata, actúa reconociendo patrones moleculares asociados a microorganismos y patógenos, provenientes de ambiente extracelular. Su función principal es la ...

    Biomarcadores y genes relacionados con alteraciones en ganglios basales en la infancia 

    Martí Sánchez, Laura (Date of defense: 2020-12-18)

    Esta tesis es el resultado de un proyecto multicéntrico y traslacional en pacientes pediátricos con trastornos del movimiento y alteraciones en los ganglios basales, centrándose en la parte bioquímica y genética desde un ...

    Combined Therapies for Neuroblastoma Based on the Activation of the Calcium- Sensing Receptor 

    Gonçalves Alves, Eliana Carolina (Date of defense: 2021-01-15)

    [eng] Neuroblastoma (NB) is the most common extracranial solid childhood tumour. Its clinical and histological manifestations range from benign tumours that spontaneously regress to highly aggressive metastatic tumours ...

    Control of integrin-mediated mechanoresponse by binding partners and force loading rates 

    González Tarragó, Víctor (Date of defense: 2019-07-11)

    This thesis is a study on the integrin-mediated mechanoresponse by binding partners and force loading rates. Regarding the binding partners, here we demonstrate an alternative and counter-intuitive mechanism, by which ...

    Estudios de biomarcadores y de posibles terapias en la deficiencia del transportador de creatina y en la enfermedad de Niemann-Pick tipo C 

    Pajares García, Sonia (Date of defense: 2016-10-03)

    En esta tesis se estudian dos aspectos, el desarrollo de herramientas diagnósticas y terapéuticas aplicado a dos enfermedades metabólicas hereditarias: la deficiencia del transportador de creatina (CRTR) y la enfermedad ...

    Genomic determinants of chronic lymphocytic leukemia progression: from individual drivers to a heterogeneous genetic makeup 

    Nadeu Prat, Ferran (Date of defense: 2020-09-23)

    Chronic lymphocytic leukemia (CLL) is the most common form of adult leukemia in Western countries. Although the disease might follow an indolent course, it rapidly progresses in a fraction of cases, become resistant to ...

    Implicació de la senyalització dependent de Gsα en l’establiment de la massa cel·lular β 

    Serra Navarro, Berta (Date of defense: 2018-07-13)

    La regulación y potenciación de la proliferación de la célula β pancreática es un objetivo principal en la prevención y/o retardo de la diabetes. Su replicación se regula a través de un proceso dinámico, siendo muy elevada ...

    Molecular and cellular mechanisms of fertilization failure after ICSI 

    Torra Massana, Marc (Date of defense: 2019-07-10)

    La ICSI és una tècnica de reproducció assistida molt eficient, però la fallada de fecundació (FF) pot ocórrer en un 1-3% dels cicles. La FF té un elevat impacte en els pacients i és molt difícil de predir, diagnosticar i ...

    Molecular mechanisms of resistance to therapy in glioblastoma 

    Pedrosa, Leire (Date of defense: 2020-10-30)

    [cat] El glioblastoma (GBM) és el tumor primari cerebral més freqüent i més agressiu. Els pacients amb GBM tenen una supervivència mitjana de 15 mesos. Una dels principals dificultats que presenten els GBMs per ser tractats ...

    New experimental approaches to study the relevance of the TGF-β and EGFR signalling during liver tumorigenesis 

    Caballero Díaz, Daniel (Date of defense: 2018-02-09)

    Hepatocellular Carcinoma (HCC) is one of the most common cancers. During hepatocarcinogenesis (a multistep process) there is a disruption of the balance between cell death and survival signalling pathways, where pro-apoptotic ...

    Papel de proteínas de la familia Bcl-2 en el estrés metabólico. Implicación en cáncer y en daño neuronal por isquemia 

    Galindo Moreno, Javier Jesús (Date of defense: 2015-04-25)

    La apoptosis es un proceso biológico fuertemente conservado a lo largo de la evolución que consta de un sistema de regulación complejo en el que intervienen gran cantidad de proteínas, en su mayoría relacionadas con la ...

    Paper de les cèl·lules progenitores hepàtiques en l’hepatitis alcohólica i la regeneració hepàtica 

    Rodrigo Torres, Daniel (Date of defense: 2016-02-05)

    La malaltia hepàtica per consum d'alcohol és una hepatopatia crònica amb alta taxa de mortalitat. Aquests pacients poden presentar episodis d'hepatitis alcohòlica (HA), caracteritzats histològicament per dany hepatocel·lular, ...

    Polycomb and KDM6A Roles in the Epigenetic Dynamics of Ewing Sarcoma Tumorigenesis 

    Figuerola Bou, Elisabet (Date of defense: 2019-12-05)

    Ewing sarcoma (ES) is a highly aggressive tumour of the bone and soft tissue that typically affects children, adolescents, and young adults. The fusion protein EWSR1‐FLI1 is the main genetic alteration found that acts as ...

    Regulation of Sirtuin-dependent skin cell Senescence by dermatology-associated compounds 

    Martínez Gutiérrez, Alfredo (Date of defense: 2019-12-13)

    One of the main causal factors of skin aging is ultraviolet radiation as part of sun exposure. This radiation induces many changes at the molecular level that alter the proper function of skin biological processes, being ...

    Role of CD44 in clear cell renal cell carcinoma invasiveness after antiangiogenic treatment 

    Aparicio García, María (Date of defense: 2020-12-09)

    [eng] The arrival of antiangiogenic therapies represented a huge advance in the treatment of different tumors, such as renal carcinoma. However, despite initial good results, some tumors were able to develop different ...

    Role of ZEB1 in skeletal muscle: Regulation of cell differentiation, response to tissue damage and regeneration 

    Siles Mena, Laura (Date of defense: 2017-06-01)

    ZEB1 is a transcription factor best known for its role in cancer progression and metastasis. It is also expressed during embryonic development of different tissues although its function and mechanism of action have not ...

    Role of ZEB1 in Tumor Progression: Regulation of Cell Invasion and Senescence 

    Barrios Barri, Oriol de (Date of defense: 2017-02-03)

    The members of ZEB family of transcription factors (ZEB1 and ZEB2) are widely known for its role in epithelial-to-mesenchymal transition (EMT), a highly relevant process during development and tumor progression. In this ...

    Tracing the developmental history of B-cell tumors by DNA methylation 

    Duran Ferrer, Martí (Date of defense: 2020-11-19)

    The DNA from our cells carries the genetic information to build a human being. This information is interpreted through epigenetic marks that lead to tightly coordinated and cell type-specific gene expression programs. One ...