Advances in Asymmetric Catalytic Reactions: Novel Methodologies and Synthetic Applications 

    Bellido Muñoz, Marina (Date of defense: 2023-11-03)

    [eng] This doctoral thesis aims to explore various synthetic methodologies and their corresponding applications in the field of asymmetric catalysis. More specifically, we have focused on the preparation of prochiral ...

    Aminocyclitol and iminosugar derivatives related to Gauche disease 

    Monlleó Mas, Ester (Date of defense: 2016-11-25)

    Gaucher disease (GD) is one of the most prevalent lysosomal storage diseases.A mutation on gene gba1 generates a misfolded enzyme acid β-glucosidase. Due to this, this enzyme is not properly transported from the endoplasmic ...

    Anisotropía Magnética en Imanes Moleculares y Qubits con Complejos Metálicos de Espín ½ 

    Amoza Dávila, Martín (Date of defense: 2019-11-08)

    Esta tesis presenta una serie de estudios computacionales basados en métodos de estructura electrónica en los que se analizan la anisotropía magnética y las propiedades derivadas de esta en complejos magnéticos candidatos ...

    Aproximació a la síntesi de la iriomoteolida-2a i avaluació in silico de la interacció amb actina. Intents d’un nou mètode de RCM amb formació de dobles enllaços trisubstituïts 

    Marco Correas, Cristian (Date of defense: 2019-10-23)

    La present Tesi Doctoral descriu tots els esforços dedicats a la síntesi total de la iriomoteolida- 2a, un nou macròlid aïllat per Tsuda i col·laboradors a l’illa d’Iriomote (Japó) l’any 2015. Exhibeix una moderada ...

    Bioconjugació de poliols i tiols amb agents antivírics 

    Petit Roig, Elena (Date of defense: 2019-10-29)

    El VIH-1 segueix essent un dels problemes més greus de la sanitat pública mundial, especialment als països del tercer món. La fase més avançada de la infecció pel VIH és la SIDA (síndrome d’immunodeficiència adquirida). La ...

    Carbazole-Based Materials for Organic Thin-Film Transistors and Organic Light-Emitting Diodes 

    Reig Canyelles, Marta (Date of defense: 2017-07-07)

    This thesis deals with the preparation and characterization of novel organic semiconductors based on the carbazole heterocycle for electronic and optoelectronic applications, specifically to be studied as active layers in ...

    Chemical tools to investigate the role of sphingolipids in disease 

    Ordóñez Vivanco, Yadira (Date of defense: 2016-09-16)

    Sphingolipids (SLs) encompass a large and diverse family of lipids that are essential constituents of cellular membranes. In addition to their structural functions, SLs are also emerging as important signalling molecules ...

    Compostos de coordinació magnètics i/o luminescents derivats d'elements 3d o 4f: Cercant sistemes multipropietat 

    Casanovas Bayo, Berta (Date of defense: 2018-06-12)

    Amb l’objectiu d’obtenir materials moleculars amb una o més propietats físiques tals com magnètiques, luminescents i/o quirals en aquest treball s’han obtingut nous compostos de coordinació basats en metalls de transició, ...

    Compostos organometàl·lics amb fosfines P-esterogèniques diaríliques: aplicacions en catàlisi homogènia enantioselectiva 

    Clavero Puyal, Pau (Date of defense: 2016-07-25)

    La Tesi tracta sobre la preparació i l’ús en catàlisi homogènia asimètrica de lligands fosforats quirals amb àtoms de fòsfor estereogènics. En primer lloc es descriu la preparació i caracterització de lligands monofosforats ...

    Computational insights into carbohydrate epimerase mechanisms 

    Esquivias Bautista de Lisbona, Oriol (Date of defense: 2023-11-17)

    [eng] Carbohydrates, as the most abundant biomolecules, play a myriad of roles and functions in biological systems. Unlike the building blocks of proteins, amino acids, whose chemical structure can vary significantly, ...

    Conformational and mechanistic analyses of α- and β-glycosidase substrates by ab initio QM/MM methods 

    Alonso Gil, Santiago (Date of defense: 2017-07-12)

    Carbohydrates are one of the most important biochemical molecules due to their role as energetic resource for non-photosynthetic organisms, cell-cell recognition and adhesion, protection of cell membranes of bacteria and ...

    Coordination, organometallic and supramolecular chemistry approaches to the design of metal-based cytotoxic agents 

    Faustino Brissos, Rosa Maria (Date of defense: 2018-04-13)

    The discovery of cisplatin and its successful use as chemotherapeutic agent have encouraged the development of metal-based anticancer molecules. The present doctoral research project includes three different chemistry ...

    COUPY coumarins as privileged scaffolds for the development of novel targeted fluorophores and metalbased PDT anticancer agents 

    Rovira Vidal, Anna (Date of defense: 2023-03-03)

    [eng] In this Thesis, we have explored the applications in cancer diagnosis and therapy of COUPY fluorophores, a new family of compounds based on the coumarin structure and operating in the far-red to near infrared region ...

    Cyclometallated platinum compounds: optical and biological applications 

    Lázaro Palacios, Ariadna (Date of defense: 2023-05-05)

    [eng] This Doctoral Thesis is focused on the synthesis of cyclometallated platinum compounds with different structural modifications rationally designed specifically for biological or optical applications. Specifically, ...

    Desenvolupament d'una síntesi industrialitzable d'un fàrmac 

    López Barallobre, Blanca (Date of defense: 2016-09-21)

    Posar al mercat un nou fàrmac és un procés molt llarg i costós i que comporta un risc econòmic important per una empresa farmacèutica. En canvi, el desenvolupament d'un procediment millorat per a la producció d'un fàrmac ...

    Desenvolupament de processos per a la síntesi de pèptids d’interès terapèutic a escala industrial 

    Duran Corbera, Macarena (Date of defense: 2021-09-30)

    Investigacions recents en el camp de la biomedicina han demostrat que les interaccions entre pèptids i macromolècules com ara les proteïnes, modulen i regulen processos biològics importants com la memòria, la resposta a ...

    Design and preparation of functional coordination compounds based on poly-β-diketone and polypyrazolyl ligands 

    Borilović, Ivana (Date of defense: 2018-11-23)

    Combining the judiciously designed bis−β-diketone and polypyrazolyl scaffolds with the crystal field effects on the 3d metal ions, this manuscript exposes different methods of selective preparation of new heterometallic ...

    Design and synthesis of photoswitchable coordination complexes 

    Salinas Uber, Jorge (Date of defense: 2016-07-29)

    One of the main objectives of this thesis was the synthesis of new chelating ligands containing a photochromic unit able to change its conformation upon light irradiation. This isomerization should serve to modify the ...

    Design and synthesis of selective MMP-9 inhibitors for the treatment of epilepsy 

    Bertran Junqué, Alexandra (Date of defense: 2018-10-25)

    Matrix metalloproteinases (MMPs) are a family of zinc-containing endopeptidases involved in the degradation of the extracellular matrix. They make a major contribution to the progression of a vast number of diseases, ...

    Design of Catalytic Systems based on Halogen Bonding Interactions: Synthesis and Application in Catalytic Reactions 

    Martínez Bascuñana, Alba (Date of defense: 2023-09-01)

    [eng] The use of supramolecular interactions in catalysis has been widely studied and exploited for the straightforward preparation of the backbones of an array of structurally diverse stereoselective catalysts. In addition ...