Universitat de Barcelona
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L’adenocarcinoma ductal pancreàtic (PDAC) és una neoplàsia molt agressiva a conseqüència de la seva elevada capacitat metastàtica i la gran resistència que presenta als tractaments convencionals de quimioteràpia i radioteràpia. ...
Catecholamines, including dopamine (DA) and norepinephrine (NE), are widely distributed in the body and constitute a class of conventional neurotransmitters and hormones that occupy key positions in the regulation of ...
Tanto la infección por el virus VIH como el tratamiento antirretroviral se asocian con el desarrollo de alteraciones metabolicas relacionadas con la adiposidad, pudiendo íncluso desarrollar lipodistrofia. Estudios previos ...
[eng] The understanding of proteins as dynamical entities rather than static structures marked a very significant advance in the interpretation of their functional role in life. The capacity of proteins to interact with ...
El teixit adipós marró (TAM) està format principalment per adipòcits marrons, la funció principal dels quals és el manteniment de la temperatura corporal de l’organisme a través de la termogènesi adaptativa. La capacitat ...
An unbalanced, unhealthy diet is one of the main causes leading to obesity and the apparition of comorbidities. Bariatric surgery is currently the most effective and durable treatment against obesity. Despite being a ...
The vascular endothelium is one of the major targets of oxidative stress, playing an important role in the development of vascular-related disorders, such as atherosclerotic disease1. Oxidative stress increases the formation ...
Voltage gated K+ channels (Kv) are transmembrane proteins that allow the pass-thorugh of potassium ions, regulating the electrochemical gradient of the cell membrane. This way, they modulate several physiological processes, ...
Los isoprenoides (o terpenoides) constituyen una vasta familia de compuestos de muy diversa naturaleza estructural y funcional presentes en todos los seres vivos. Los isoprenoides sintetizados por las plantas representan ...
The wide variety of disorders associated with the malfunction of amino acid (AA) transporters reflect the relevant roles they fulfil in human physiology. Heteromeric AA transporters (HATs), one of the eleven families of ...
The endothelium plays a pivotal role in the development of cardiovascular disease (CVD) and emerging evidence indicates that pathological blood vessel responses and endothelial dysfunction are associated with metabolic ...
Leukaemia is one of the types of cancer where treatment resistance is prevalent. Better understanding of leukemic cells metabolism opens possibilities for new therapeutic strategies and better prognosis stratification. ...
Actualmente, entre el 30-40% de los medicamentos comercializados tienen como diana a un receptor acoplado a proteína G (GPCR). Además, la capacidad que tienen estos receptores para interaccionar físicamente entre ellos y ...
Cancer cells, including leukemic cells, can react to therapeutic treatment by altering their metabolic phenotype (“metabolic reprogramming”) to keep their accelerated proliferative state, eventually becoming resistant to ...
Els nucleòsids són metabòlits imprescindibles per a la cèl·lula ja que són els precursors d’un gran nombre de biomolècules. Aquests nucleòsids poden ser sintetitzats per la cèl·lula o es poden recuperar del medi extracel·lular ...
[eng] Next-generation sequencing (NGS) has revolutionized biomedical sciences, especially in the area of cancer. It has nourished genomic research with extensive collections of sequenced genomes that are investigated to ...
Metabolism is a hallmark of life and underlies most biological processes in both health and disease. For instance, dysregulation of liver metabolism underlies multifactorial disorders such as diabetes or obesity. Similarly, ...
El cáncer de colon representa entre el 10-12% de las enfermedades neoplásicas y es una de las causas principales de muerte por cáncer en los países occidentales. Fármacos como el irinotecan, inhibidor de la topoisomerasa ...
[spa] Aún queda mucho por conocer sobre la regulación de la función de los transportadores concentrativos de nucleósidos hCNTs. A pesar de que se expresan en muchos tipos de tejidos, su localización no es ubicua y varía ...
En la enfermedad de Huntington (HD), muchos síntomas están asociados con alteraciones en las funciones reguladas por la dopamina y el glutamato; una intervención directa sobre los receptores de dopamina D1 (D1R) pueden ...
