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Functional implications of protein kinase CK2 in F-actin dynamics and in the cross-talk between auxin and salicylic acid signalling pathways in arabidopsis thaliana
El objetivo de esta tesis era el estudio del papel de la proteina CK2 en tres procesos biológicos de plantas, utilizando Arabidopsis thaliana como modelo: fototropismos, regulación de las vías de señalización del ácido ...
Functional interactions of Infralimbic-Cerebellum pathways in cocaine-induced preference memory
The present thesis investigates the cerebellum-IL interactions in drug-induced memories and their anatomical pathways. To do so, we 1) assessed activity and perineuronal nets (PNNs) expression in the posterior cerebellum ...
Functional interplay between ER and MAF transcription factors in breast cancer bone metastasis
Metastatic breast cancer (BCa) is the leading cause of death in BCa patients. Current therapies for BCa aim at cell proliferation and, therefore, latent disseminated cells are able to escape treatment. For this reason, ...
Functional interplay of two SWI/SNF chromatin-remodeling accessory subunits during C. elegans development
El complexos SWI/SNF són remodeladors de cromatina dependents d’ATP que es troben altament conservats al llarg de l’evolució. Aquests complexos poden regular l’accessibilitat a una zona genòmica alterant l’estat de la ...
Functional interplays of proteins and proteases: AD13-VWF, TGFβ2-α2M, and the proteolysis of gliadin by neprosin
The present thesis has established a new and state of the art mammalian protein expression system at the laboratory which has then contributed with high-yield expression for the purification and crystallization of three ...
Functional Nanomaterials from the Bottom-up Assembly of Colloidal Nanoparticles. A Strategy Towards Efficient Thermoelectrics
The work developed during this PhD has embraced several topics that I divide in three blocks. Each block contains two chapters in this dissertation. Additionally, a general introduction of the different topics is provided ...
Functional oligonucleotide recognition nanomodules for electrochemical DNA biosensors
The goal of this thesis has been to design, characterise and optimise an electrochemical DNA sensor array. In order to investigate the oligonucleotide probe immobilisation and the hybridisation detection, preliminary ...
Functional organization and networ resilience in self-organizing clustered neuronal cultures
Major dynamical traits of a neuronal network are shaped by its underlying circuitry. In several neurological disorders, the deterioration of brain's functionality and cognition has been ascribed to changes in the topological ...
Functional oxide films and interfaces: ferroelectric BaTiO3 films on Si(001) and conducting (110) and (111) LaAlO3/SrTiO3 interfaces
La tesis aborda la integración monolítica de óxidos funcionales sobre silicio y la exploración de intercaras entre SrTiO3(110), SrTiO3(111) y otros óxidos En primer lugar la tesis detalla la integración monolítica del ...
Functional performance in physically frail community dwelling older adults
En països desenvolupats, la característica demogràfica actual més rellevant és l'envelliment de la població. Tenint en compte el percentatge de gent gran i la tendència de la població en el futur, es considera essencial ...
Functional Profiling of PIF3 Regulated Genes in the Dark / Análisis funcional de los genes regulados por PIF3 en oscuridad
After germination in darkness, Arabidopsis seedlings follow a dark specific developmental pattern called skotomorphogenesis or etiolation, characterized because the plant develops long hypocotyls together with a closed ...
Functional profiling of the human gut microbiome using metatranscriptomic approach
Fins ara, les aproximacions meta-òmiques utilitzen tecnologies de seqüenciació d'alt rendiment, que produeixen una quantitat enorme de dades, desafiant així els ordinadors moderns actuals. Hem desenvolupat una nova pipeline ...
Functional properties and applications of plasma polymerized hexamethyldisiloxane (ppHMDSO) thin films
Plasma Polymerization is a novel technique for the preparation of polymer-like thin film coatings at low temperatures onto almost any type of substrates: plastic, metal, semiconductors, wood, textile fibers or membranes, ...
Functional responses of pre- and postsynaptic dopamine D2 receptors in rat brain striatum
El sistema dopaminèrgic has estat molt estudiat en els darrers anys, principalment degut a la seva implicació en diverses patologies com la malaltia de Parkinson, la esquizofrènia o la síndrome de Tourette, així com també ...
The functional role of emergent macrophytes in nature-based solutions (NBS) aiming to mitigate nutrient loading in freshwater ecosystems
Freshwater degradation has been largely attributed to excess nutrient concentrations of anthropogenic origin. Freshwater degradation in combination with water scarcity are the reason of severe stress on water resources ...
Functional role of extracellular matrix proteins and their receptors in apoptosis and cell survival
Macrophages require presence of M-CSF to survive and proliferate. Incubation of bone marrow macrophages with soluble factors (LPS or IFN-gamma) or insoluble factors such as extracellular matrix proteins (Decorin, FN) ...
Functional Role of Glycogen synthase Kinase-3β on Glucocorticoid-mediated signaling
Glucocorticoids (GC) induce cell cycle arrest and apoptosis in different cell types and therefore are widely used to treat a variety of diseases including autoimmune disorders and cancer. This effect is mediated by the GC ...
Functional role of pentose phosphate pathway and glutamine in cancer cell metabolism
In this thesis, tumor metabolic reprogramming has been exploited in order to propose new targets in cancer treatment. On one hand, we explored the pentose phosphate pathway (PPP) enzymes as putative therapeutic targets ...
Functional studies of 4F2hc-CD147 interaction = Estudios funcionales de la interacción 4F2hc‐CD147
We identified proteins that interacted with the ectodomain of 4F2hc, a plasma membrane protein with dual function as heavy subunit of the amino acid transporters and positive regulator of β1 and β3 integrins. Initially, ...
Functional studies on the circadian regulation of mitochondrial activity in Arabidopsis thaliana
El reloj circadiano es un mecanismo celular endógeno capaz de medir el paso del tiempo y traducir las señales medioambientales, principalmente luz y temperatura, en respuestas temporales que resultan en ritmos metabólicos ...
