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Now showing items 22964-22983 of 41808
Investigating the factors influencing professional identity on first-year university students: an exploratory study
Considerant que la Identitat Professional actua com a mediadora de la decisió d’escollir un determinat camí professional, la present tesi té com objectiu contribuir en el coneixement sobre aquest fenomen, en l’àmbit ...
Investigating the genetic component of Parkinson’s disease through the use of human induced pluripotent stem cells and gene editing
Despite the advances in the identification of genes and proteins involved in Parkinson’s disease (PD), there are still appreciable gaps in our understanding of the mechanisms underlying the chronic neurodegenerative process ...
Investigating the Middle to Upper Paleolithic Transition from the Sites in Khorramabad Valley; Western Iran: with Special Reference to Kaldar Cave
Aquesta tesi doctoral conté una recerca dirigida a la comprensió de la transició del Paleolític mitjà al superior a les muntanyes del Zagros, i de les seves implicacions en debats mes globals. Aquesta recerca és el resultat ...
Investigating the molecular basis of Drosophila L(3)mbt and pins malignant tumors
Genetically tractable model organisms may help to identify new approaches to stop malignant growth. During the first part of my doctoral thesis, I have participated in a high content screen carried out to this end taking ...
Investigating the role of Gli2 in mouse embryonic stem cells and mouse embryogenesis
Embryonic stem cells (ESCs) are derived from the inner cell mass of the pre-implantation embryo and can recapitulate early developmental stages of the embryo. ESCs have the ability to continuously propagate while maintaining ...
Investigating the role of mitochondrial dysfunction in the pathogenesis of Parkinsons´s disease using patient-specific derived astrocytes
Parkinson’s disease (PD) is an incurable, chronically progressive disorder of old age leading to premature invalidity and death. Clinically, PD is characterized by classical motor syndrome linked to a progressive loss of ...
Investigating the role of testis-mitochondiral genes in Drosophila lethal (3) malignant brain tumor
Genetically tractable models such as Drosophila melanogaster may help to identify new approaches to halt malignant growth. During my doctoral thesis, I performed a screen to find mitochondrial genes required for the growth ...
Investigating the role of transcription factor Nkx1-2 in mouse embryonic stem cell pluripotency, self-renewal and differentiation
Mouse embryonic stem cells (ESCs) require extracellular signals to induce the expression of intrinsic core pluripotency factors: Oct4, Sox2 and Nanog, known as the OSN triad. Notably, the Wnt/β-catenin pathway has been ...
Investigating the role of Wnt/β-catenin pathway in pluripotency and somatic cell reprogramming
The adaptive response of cells to external stimuli is an intriguing mechanism at the basis of the existence of life itself. For this purpose, signalling pathways and gene regulatory networks elegantly evolved translating ...
Investigating the roles of cellular senescence in embryogenesis and aging
Cellular senescence is an irreversible form of proliferative arrest, historically linked to tumour suppression and aging. Recent discoveries, however, have extended its known role to include complex biological processes ...
Investigating the Signs and Sounds of Cypro-Minoan
The aim of this dissertation is to advance our knowledge of Cypro-Minoan, a group of undeciphered syllabic inscriptions dated roughly to the 16th or 15th through the 11th centuries BCE and found mostly on Cyprus, with small ...
Investigation of branched and linear polymers as oral delivery systems of antimalarial drugs
Malaria is an infectious disease that affects nearly half of the population in 90 countries around the world. In 2017 it was estimated that there were 219 million cases and 435,000 deaths disproportionately distributed ...
Investigation of continuous-wave range-resolved lidar systems for gas detection and concentration measurement
The techniques for detection of the atmosphere constituents and their distribution in the space have evolved in the last years driven by needs in the environmental, meteorological and climate science fields and backed by ...
Investigation of protein-ligand interactions using high-throughput all-atom molecular dynamics simulations
Investigation of protein-ligand interactions has been a long-standing application for molecular dynamics (MD) simulations given its importance to drug design. However, relevant timescales for biomolecular motions are orders ...
Investigation of reflective optical network units for bidirectional passive optical access networks
Esta investigación está conducida a la resolución del problema de encontrar soluciones rentables para el despliegue de redes de fibra hasta el hogar (Fibre to the Home - FTTH). En una red de FTTH, el equipo transmisor-receptor ...
Investigation of the antioxidant properties of five aromatic plants in model food systems
In this PhD it has been analyzed the antioxidant activity of five plants: Camelia sinensis, Gentian lutea, Betula pendula, Convolvulus arvensis and Arctostaphylos uva-ursi. An Electronic Paramagnetic Resonance has been ...
Investigation of the influence of the membrane lipid environment on g protein-coupled receptor activation by molecular dynamics simulations
Els receptors acoblats a proteïnes G (GPCRs) són importants dianes terapèutiques per a nombroses malalties. Si bé els GPCRs s’han estudiat àmpliament en les últimes dècades, els mecanismes moleculars que determinen la seva ...
Investigation of the phospholipid peripheral region of lactose permease in model membranes
The interaction between a membrane protein and its surrounding phospholipids is thought to be crucial for the correct folding and function of the protein. This thesis is focused on the investigation of the interplay between ...
Investigation of the role and modulation of autophagy for neuroprotection and nerve regeneration using models of peripheral nerve injury
Lesiones en el nervio periférico causan una disrupción axonal que puede producir una neurodegeneración retrograda. Las neuronas axotomizadas sufren una serie de cambios fenotípicos a nivel molecular y celular, algunos de ...
Investigation of the telomere maintenance system in Cushing’s syndrome: A contribution to the phenomena of early ageing and specific morbidity
La síndrome de Cushing (SC), una malaltia minoritària per secreció excessiva de cortisol, s'associa a augment de morbi-mortalitat, inclús després del tractament, comparat amb població de referència i s'associa a processos ...
