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Protective role of polyethylene glycol 35 against hepatic cold and warm ischemia
Steatotic livers are considerably more prone to IRI, in which turn, it is known to impair mitochondrial function. Our working hypothesis lies on the fact that impaired mitochondrial function and reduced protection against ...
Protectores ambientales de estrés laboral hospitalario
In this study the development of the ENPROS instrument (Environmental Safeguards against hospital work Stress) is reported. It measures environmental safeguards from hospital work stress. ENPROS is a 45-item instrument ...
Protein adsorption and macrophage polarization as biocompatibility markers for biomaterial design
The standard protocol before proceeding to clinical trials of a biomaterial is to follow a battery of determined in vitro following in vivo experimentation. The lack of correlation between in vitro and in vivo experimentation ...
Protein dynamics studied by coarse-grained and atomistic theoretical approaches
Protein structure, dynamics and function, are inseparable in order to understand the mechanisms of Life at the molecular level. From the structure comes dynamics, and from dynamics many, if not all, protein functions. ...
Protein Flexibility: From local to global motions. A computational study
Proteins are flexible entities, and thus move. Its function is closely related to the flexibility. To carry out any function is necessary a conformational change. As protein motions imply an exchange of conformations, ...
Protein Interaction networks and their applications to protein characterization and cancer genes prediction
La importancia de comprender los procesos biológicos ha estimulado el desarrollo de métodos para la detección de interacciones proteína-proteína. Esta tesis presenta PIANA (Protein Interactions And Network Analysis), un ...
Protein kinase-dependent Kv1.3 biology
[eng] The voltage gated potassium channel Kv1.3 is a transmembrane protein that selectively drives potassium ions participating in the electrochemical gradient of cell membranes. This channel presents a wide distribution ...
Protein reporters to study in vivo protein interactions and aggregation
L'objectiu dels dos primers capítols va ser l'aplicació de la tècnica "Bimolecular fluorescent protein complementation" (BIFC) per a detectar interaccions intracel·lulars proteiques de caràcter dèbil in vivo. Durant l'estudi ...
Protein signatures in uterine aspirates to improve diagnosis of endometrial cancer "The CEMARK project"
Alrededor del 30% de las pacientes con cáncer de endometrio (CE) son diagnosticadas en un estadio avanzado de la enfermedad, asociado con un drástico descenso de la supervivencia a los 5 años. El diagnóstico se realiza ...
Protein solvation preferences: applications to drug discovery
Computer-aided drug design is a key player in current drug discovery projects. Structure-based computational approaches use the target structural information to suggest potentially active and safe drugs. However, the process ...
Protein-Based Targeted Delivery Systems for Antimicrobial Photodynamic Inactivation
Des de la introducció dels antibiòtics, els microorganismes han començat a desenvolupar resistència a ells i, avui dia, a causa de l'abús d'aquests fàrmacs i la manca de descobriment de noves classes d'antibiòtics, la ...
Protein-ligand binding sites. Identification, characterization and interrelations
El trabajo presentado en esta tesis cubre varios campos de investigación relacionados con el desarrollo de moléculas bioactivas. Se compone de cinco partes distintas que se resumen aquí. Predicción de la utilidad ...
Protein-protein docking for interactomic studies and its aplication to personalized medicine
Proteins are the embodiment of the message encoded in the genes and they act as the building blocks and effector part of the cell. From gene regulation to cell signalling, as well as cell recognition and movement, ...
Protein-protein interaction network : management of databases and its applications on the computational study of protein-protein interactions
The use of protein-protein interaction networks has become crucial due to the emergence of systems biology. The completeness and quality of networks, crucial to understand the biochemical mechanisms underlying a system ...
Proteina transportadora de retinol tipo 4 (RBP4) en la obesidad : niveles plasmáticos y expresión en grasa subcutánea
DE TESIS DOCTORAL<br/>Título de la tesis:<br/>Proteína transportadora de retinol tipo 4 (RBP4) en la obesidad.<br/>Introducción:El RBP4 es una adipoquina recientemente descrita (Janke et col, Diabetes 2006). Ha sido ...
Proteína asP1a/4 y el ciclo biológico de astrovirus: aplicación en epidemiología molecular, La
Los astrovirus son unos virus icosaédricos de pequeño tamaño con un genoma ARN monocatenario de polaridad positiva y 3 pautas abiertas de lectura (ORF1a y ORF1b para las proteínas no estructurales, y ORF2 para las proteínas ...
Proteína inmunodominante P116 del patógeno humano Mycoplasma pneumoniae: un recipiente para el colesterol y otros lípidos esenciales
[spa] Mycoplasma pneumoniaees una bacteria patógena humana sin pared celular que causa neumonías atípicas y otras infecciones respiratorias. Es una de las pocas especies de procariotas que necesitan lípidos en la integridad ...
Proteína multifuncional ADE2 como nexo entre vías de recuperación y síntesis de novo de nucleótidos
Nucleosides and nucleotides have a key role in cell physiology being implicated in crucial processes such as DNA and RNA synthesis, cell signaling and metabolic regulation. Purine and pyrimidine nucleotide balance is ...
La proteína priónica celular: Análisis de su función neuroprotectora y reguladora del ciclo Celular
Las encefalopatías espongiformes transmisibles (EETs) son un conjunto de enfermedades neurodegenerativas letales que afectan tanto animales como humanos. Están causadas por unas partículas proteicas denominadas “priones”, ...
La proteína quinasa C épsilon en la unión neuromuscular de mamífero adulto: Localización, regulación mediante actividad sináptica y acoplamiento a la liberación de acetilcolina
La proteïna quinasa C (PKC) pertany a la família de les serina/treonina quinases y participa en diferents de senyalització regulant diverses funcions neurals. Les proteïnes d’unió a PKC intracel•lulars ,conegudes com ...
