Ara mostrant els elements 1-10 de 13
Tarrado Castellarnau, Miriam Neus (Data de defensa: 2015-12-11)
Cancer is characterised by the lost of physiological control and the malignant transformation of cells that acquire functional and genetic abnormalities, leading to tumour development and progression. ...
Aguilar Fadó, Esther (Data de defensa: 2015-02-23)
Metastasis represents the most life-threatening aspect of tumorigenesis and is the leading cause of death by cancer. Intensive research in this field has shed light on some of the molecular strategies ...
Matito Sánchez, Cecilia (Data de defensa: 2006-01-13)
Cancer is one of the leading causes of death in countries throughout the world. Increase in the production of Reactive Oxygen Species (ROS) has been implicated in many human disease processes, including ...
Carreras Cardona, Anna (Data de defensa: 2012-05-04)
During aerobic cell metabolism, molecular oxygen is reduced to water through electron-transfer reactions, and the oxygen not completely reduced is transformed into a set of neutral and free radical ...
Contreras Mostazo, Miriam Guadalupe (Data de defensa: 2020-10-21)
Cancer cells, including leukemic cells, can react to therapeutic treatment by altering their metabolic phenotype (“metabolic reprogramming”) to keep their accelerated proliferative state, eventually ...
Tarragó Celada, Josep (Data de defensa: 2020-09-16)
Metastasis is the main cause of cancer-related deaths and it is of great biomedical importance to develop new therapeutic strategies that specifically target metastatic cells. Therefore, a better ...
Balcells Nadal, Cristina (Data de defensa: 2019-12-19)
Metastasis and drug resistance represent the two main causes of therapeutic failure in oncology. In the present dissertation, the interplay between them has been interrogated using metabolomics, systems ...
Polat, Ibrahim H. (Data de defensa: 2016-11-04)
In this thesis, tumor metabolic reprogramming has been exploited in order to propose new targets in cancer treatment. On one hand, we explored the pentose phosphate pathway (PPP) enzymes as putative ...
Zodda, Erika (Data de defensa: 2019-12-13)
The endothelium plays a pivotal role in the development of cardiovascular disease (CVD) and emerging evidence indicates that pathological blood vessel responses and endothelial dysfunction are associated ...
Baptista, Inês do Carmo Viegas (Data de defensa: 2022-04-07)
Leukaemia is one of the types of cancer where treatment resistance is prevalent. Better understanding of leukemic cells metabolism opens possibilities for new therapeutic strategies and better prognosis ...