Mostrando ítems 1-9 de 9
Rosselló Tortella, Margalida (Fecha de defensa: 2021-12-09)
Transfer RNAs (tRNAs) are essential molecules that allow the translation of the genetic code into amino acids. Extensive research during the last 50 years have revealed that, despite their apparently ...
Szczesna, Karolina (Fecha de defensa: 2014-09-26)
INTRODUCTION: In 1966, Rett syndrome (RTT, OMIM#312750) was for the first time described as a clinical issue by Dr. Andreas Rett, an Austrian pediatrician. He has observed in 22 patients similar ...
Pérez Salvia, Montserrat (Fecha de defensa: 2019-03-01)
Cancer is considered nowadays a genetic and epigenetic disease. Aberrancies in epigenetic marks in DNA and histone tails together with alterations in epigenetic regulators responsible of catalyzing ...
Lucariello, Mario (Fecha de defensa: 2017-03-16)
STUDY I HYPOTHESIS Genetic alterations have already been recognized as major etiological factors for ASD and ID, of which RTT is an example. In addition to the contribution of polymorphic variants ...
Oliveira Mateos, Cristina (Fecha de defensa: 2020-06-16)
The vast majority of the human genome is transcribed giving rise to non-coding RNAs. Antisense transcripts are one of the most abundant types of long non-coding RNAs and many of them have regulatory ...
Ortiz Barahona, Vanessa (Fecha de defensa: 2022-04-01)
The general aim of this thesis is to identify and characterize if there are DNA methylation patterns giving rise to cancer-related m5C RNA modification defects, potentially promoting malignant transformation ...
Coll San Martín, Laia (Fecha de defensa: 2021-11-29)
Cancer was reported as the second leading cause of death in 2018 by the World Health Organisation. Cancer is defined as the set of diseases that proceeds in multiple phases generating a transformation ...
Petazzi, Paolo (Fecha de defensa: 2015-02-20)
INTRODUCTION To answer many complex and fascinating biological phenomena, we must go over or above (epi-) genetics because the DNA blueprint is identical in each of the abovementioned somatic cells. ...
Moutinho, Cátia (Fecha de defensa: 2014-05-23)
Although chemotherapeutic drugs are widely used in order to improve the cancer outcome, drug resistance remain the most unpredictable factor affecting chemotherapy and a major impediment to successful ...