Rosselló Tortella, Margalida (Date of defense: 2021-12-09)
Transfer RNAs (tRNAs) are essential molecules that allow the translation of the genetic code into amino acids. Extensive research during the last 50 years have revealed that, despite their apparently ...
Solé Acha, Xavier (Date of defense: 2012-03-07)
Al llarg de les dues darreres dècades hem tingut el privilegi d’assistir a un dels esdeveniments més importants en la història de la biomedicina: el desenvolupament del Projecte Genoma Humà. Conjuntament ...
Jiménez Flores, Lizbeth Minerva (Date of defense: 2018-11-09)
Gastric cancer (GC) is one of the most common types of cancer in the Western World and accounts for over 700,000 deaths every year worldwide. The prognosis is dismal, with an average 5-year survival ...
Pérez Salvia, Montserrat (Date of defense: 2019-03-01)
Cancer is considered nowadays a genetic and epigenetic disease. Aberrancies in epigenetic marks in DNA and histone tails together with alterations in epigenetic regulators responsible of catalyzing ...
Celià Terrassa, Antoni (Date of defense: 2012-05-14)
This Doctoral Thesis project is part of a broader research program whose global aim is to better understand key molecular and cellular events in tumor metastasis, in particular those associated with ...
Royo Garrido, Romina (Date of defense: 2023-03-31)
[eng] Next-generation sequencing (NGS) has revolutionized biomedical sciences, especially in the area of cancer. It has nourished genomic research with extensive collections of sequenced genomes that ...
Moreno Càceres, Joaquim (Date of defense: 2016-01-18)
The transforming growth factor-beta (TGF-β) is a cytokine involved in many physiological and pathological processes. Its dual role has been described in the liver, where it can either induce pro- or ...
Oliveira Mateos, Cristina (Date of defense: 2020-06-16)
The vast majority of the human genome is transcribed giving rise to non-coding RNAs. Antisense transcripts are one of the most abundant types of long non-coding RNAs and many of them have regulatory ...
Bellmunt i Tarragó, Anna (Date of defense: 2017-12-15)
The identification of genes that mediate metastasis is pivotal to better understand the mechanism, to develop novel drugs and to stratify patients with highest risk and consecutively administrate them ...
Rofes Terrón, Paula (Date of defense: 2022-03-31)
The overarching aim of the present thesis project is to implement new testing strategies and develop new tools that will contribute to improve the genetic diagnosis of hereditary cancer, with the ultimate ...