Now showing items 1-20 of 11001

    Analysis of consensus motions in proteins through molecular dynamics simulations 

    Jordà Bordoy, Luis (Date of defense: 2024-02-06)

    [eng] The understanding of proteins as dynamical entities rather than static structures marked a very significant advance in the interpretation of their functional role in life. The capacity of proteins to interact with ...

    Mechanistic insights into the role of the CPEB4 neuronspecific microexon in neurodevelopmental disorders 

    Bartomeu i Galan, Anna (Date of defense: 2024-01-29)

    [eng] Cytoplasmic Polyadenylation Element Binding proteins (CPEBs) are a family of RNA-binding proteins that regulate cytoplasmic changes in poly(A) tail lengh and therefore mRNA-specific stability and translation. Since ...

    Estudi de l’efecte dels canvis socials sobre la conducta de tres grups familiars de goril·les de plana occidental (Gorilla gorilla gorilla) captius. A la recerca d’indicadors conductuals de benestar 

    Martínez Gutiérrez, Raquel (Date of defense: 2024-01-24)

    [cat] Un dels pilars bàsics que componen la raó de ser dels parcs zoològics actuals és la conservació ex situ d’espècies amenaçades. Aquesta comesa, comporta el compliment d’una sèrie de requisits, entre ells, el de ...

    Role of kinase DYRK1A in the neurogenesis of the embryonic telencephalon 

    Trujillano Fernández, Alejandro (Date of defense: 2024-02-08)

    [eng] DYRK1A is a kinase that is expressed in virtually all tissues and cell types and is implicated in human diseases. Several studies indicate that DYRK1A is a dose-dependent gene with a prevalent function in brain ...

    Mediator complex and transcriptional control of cellular identity and plasticity 

    Calvo Serrano, Isabel (Date of defense: 2024-02-16)

    [eng] Our understanding of the transcriptional control of cellular identity is rapidly emerging. Mediator complex enriches at active enhancers, forms a protein bridge to target genes, and recruits RNA Polymerase II ...

    Genetic variability of minnows and loaches in rivers and high mountain lakes from the Pyrenees and Italian Alps 

    Suh, Jongmo (Date of defense: 2024-02-20)

    [eng] The invasion of alien species is a major global threat to ecosystems, with significant impacts, especially on freshwater ecosystems. The species diversity in freshwater ecosystems has significantly declined worldwide, ...

    Biological mechanisms underlying psychosocial stress response: The consequences of prenatal maternal distress and childhood maltreatment on the endocrine and immune systems 

    Castro Quintas, Águeda (Date of defense: 2024-02-26)

    [eng] During critical periods of development, psychosocial stress experiences may alter key neural networks of the human brain, with long-lasting effects on behavior and mental health. However, the specific biological ...

    The role of non-native fish on littoral macroinvertebrates of Pyrenean high mountain lakes 

    Osorio Álvarez, Víctor (Date of defense: 2024-02-06)

    [eng] High mountain freshwater ecosystems, such as Pyrenean lakes, are distinguished by their unique ecological characteristics, which encompass their near-pristine undisturbed state, unique biodiversity, and their role ...

    Variability in domain-scale regional mutation density across tissues and individuals 

    Salvadores Ferreiro, Marina (Date of defense: 2024-01-18)

    [eng] Mutations exhibit an uneven distribution across the human genome, with a regional mutation density (RMD) influenced by chromatin landscapes and replication timing. While there is a good understanding of this variation, ...

    An Omics World: Colonization and Adaptive Processes of Styela plicata 

    Galià Camps, Carles (Date of defense: 2024-01-22)

    [eng] In the last decades biological invasions have emerged as a global concern, as they impact local biodiversity by disrupting ecosystem functioning and ultimately affect human health, economy and wellness. In a climate ...

    Role Of The Innate Immunity In The Etiopathogenesis of Primary Sjögren Syndrome: Influence Of Viral And Immunogenetic Factors Related To Cell Adhesion Molecules In Systemic Disease And Autoantibody Profile 

    Gheitasi, Hoda (Date of defense: 2024-01-26)

    [eng] Sjögren Syndrome is a systemic autoimmune disease that affects the exocrine glands, most notably the salivary and lacrimal glands, although it can affect other mucosal surfaces. Inflammation at these sites leads to ...

    Interferon Gamma Release Assay (IGRA): implicaciones para el diagnóstico y tratamiento de la tuberculosis ocular 

    Fernández Zamora, Yuslay (Date of defense: 2022-11-24)

    [spa] OBJETIVO GENERAL: Profundizar en la comprensión y conocimiento de los aspectos esenciales de tipo traslacional (epidemiológico) y clínico (diagnóstico clínico, tratamiento y pronóstico) relacionados a la tuberculosis ...

    Herramientas para la evaluación de la eficacia de vacunas terapéuticas frente al VIH 

    Fehér, Csaba (Date of defense: 2022-11-21)

    [spa] Aunque el número de nuevos casos lleva descendiendo desde 1996, la población de personas que viven con el VIH sigue creciendo año tras año, ya que su esperanza de vida se acerca cada vez más a la población general. ...

    Characterization of the prevention and care cascade in children living with HIV in the Manhiça district, Mozambique 

    Fernández Luis, Sheila (Date of defense: 2022-11-21)

    [eng] INTRODUCTION Children acquire human immunodeficiency virus (HIV) infection mainly due to vertical transmission (VT) from their mothers, during pregnancy, delivery or breastfeeding (1). Without immediate access to ...

    El tipo de donante, la hemoglobina basal y la amplitud máxima del coágulo del tromboelastograma basal: cofactores determinantes de la transfusión de concentrados de hematíes en el trasplante hepático 

    Viguera Fernández, Laura (Date of defense: 2022-11-15)

    [spa] La primera hipótesis de esta tesis doctoral, establece que la hemoglobina basal (previa al trasplante hepático) y la amplitud máxima del coagulo del tromboelastograma, pueden predecir la transfusión intraoperatoria ...

    Paisajes de lo inesperado: esencia, entorno y procesos de experimentación en la improvisación libre 

    Tabueca Fernández, Luis (Date of defense: 2024-02-15)

    [spa] Esta tesis propone una investigación teórico-práctica en torno a la improvisación libre en el arte sonoro, la música, las artes del movimiento, el arte de acción y las artes escénicas. Está dividida en dos partes. ...

    Human pluripotent stem cells: towards the definition of new engineering approaches to target heart and kidney disease 

    Gallo, Maria (Date of defense: 2023-11-08)

    [eng] Human pluripotent stem cells (hPSCs) offer a significant advantage in recapitulating key features related to tissue differentiation, morphogenesis and, conversely, human diseases. Taking advantage of their inherent ...

    Contra el atomismo. Fundamentos de una solidaridad republicana 

    Sánchez Saumell, Daniel (Date of defense: 2024-03-15)

    [spa] El presente trabajo pretende justificar normativamente una concepción deontológica de la solidaridad como base para una solidaridad política institucionalizada. En un primer momento, se realiza una crítica al atomismo ...

    Caracterització arqueomètrica de la producció ceràmica als regnes de Còrdova i Granada entorn els segles XV-XVII 

    Valls Llorens, Marta (Date of defense: 2023-12-01)

    [cat] Aquesta Tesi Doctoral centra el focus en una recerca sobre la producció, distribució i tecnologia ceràmica als regnes de Còrdova i Granada durant l'època moderna. L'elecció d'aquesta àrea es fonamenta en dos punts ...

    Estrategias del Arte Contemporáneo Frente a la Violencia y las Relaciones de Poder 

    Botero Gómez, Yosman (Date of defense: 2024-02-22)

    [spa] Esta tesis investiga procesos de producción de diferentes artistas referentes, abordando fundamentalmente las relaciones de poder desde diferentes contextos, en donde esta vinculación se convierte en el desencadenante ...