Universitat Pompeu Fabra
Now showing items 1615-1634 of 3217
Although the dual anti-HER2 blockade with trastuzumab and pertuzumab monoclonal antibodies has improved the outcome of patients with HER2+ breast cancer, a significant number of patients relapse. Additional strategies for ...
Human cytomegalovirus (HCMV) infection induces persistent changes in the host immune system, namely a sustained expansion of effector memory and cytotoxic specific T lymphocytes, the production of antibodies (Ab) and, in ...
Deep-learning models have revolutionized state-of-the-art technologies in many research areas, but their black-box structure makes it difficult to understand their inner workings and the rationale behind their predictions. ...
El diagnóstico asistido por ordenador de enfermedades cardiovasculares (CVD) con resonancia magnética cardíaca (CMR) es un campo importante de investigación para el fenotipado avanzado de imágenes cardíacas. Las mediciones ...
En las páginas siguientes se presentan los resultados del estudio de la población de ascendencia africana sometida a esclavitud en la provincia de Honduras en la época colonial. Este esfuerzo está encaminado a analizar sus ...
The dissertation investigates the interrelationship between migration and family behaviours, marriage and fertility, in the Chinese context. I apply event history techniques using data from an ethno-survey, several ...
La tesi analitza el grau de control polític a que foren sotmeses les institucions catalanes (Diputació del General i Consell de Cent de Barcelona), per part de la monarquia, després de la Guerra dels Segadors. Des del reial ...
La tesis que aquí se presenta tiene como objetivo principal documentar la ampliación de la toma de conciencia comunicativa de dos estudiantes de ELE de nivel B2 mediante la aplicación de una secuencia didáctica en CBI ...
De la mano de una teoría de las normas integradora, este trabajo somete el principio de accesoriedad de la participación a un doble análisis: por un lado, en el nivel de la norma primaria, aspira a elucidar su significado ...
Epigenetic mechanisms, influenced by intrinsic and environmental factors are crucial for the regulation of gene expression and, ultimately, the phenotype. The European sea bass is used as a model to study these influences ...
S'ha introduït el portafoli com a instrument d'autoprenentatge i acreditació en dues modalitats diferents: el portafoli d'aprenentatge de l'estudiant i el portafoli docent del professor. El primer s'ha aplicat per al ...
El microbioma ha despertado un creciente interés científico, mediático y económico. Esta tesis examina hasta qué punto la información del microbioma en la prensa e internet está alineada con la ciencia. Durante el ...
Este trabajo es un compromiso para acercar la academia a las necesidades de la sociedad. Se trata de una investigación evaluativa, de corte cualitativo, realizada en el Instituto de Educación Superior Menéndez i Pelayo ...
P63 is a transcription factor of the p53 family with key roles in embryonic development, stem cells and cancer. P63-deficient mice fail to form stratified and glandular epithelia, including the prostate, demonstrating a ...
La localització de molècules d'ARNm permet regular la síntesi de proteïnes localment i temporalment i això és vital per molts processos cel·lular fonamentals. A Oligodendròcits el transport de l'ARNm de la proteïna bàsica ...
Cellular senescence has mainly been associated with tumor suppression and aging, mediated through cell intrinsic cell-cycle inhibition and arrest. However, through secretion of specific proteins, termed the senescence-associated ...
The aim of this thesis is to delve into sperm RNA dynamics during maturation and paternal inheritance. To obtain an integrative multi-omics view of sperm RNA during these processes, I turned to the new direct RNA sequencing ...
Genetically tractable model organisms may help to identify new approaches to stop malignant growth. During the first part of my doctoral thesis, I have participated in a high content screen carried out to this end taking ...
Embryonic stem cells (ESCs) are derived from the inner cell mass of the pre-implantation embryo and can recapitulate early developmental stages of the embryo. ESCs have the ability to continuously propagate while maintaining ...
Mouse embryonic stem cells (ESCs) require extracellular signals to induce the expression of intrinsic core pluripotency factors: Oct4, Sox2 and Nanog, known as the OSN triad. Notably, the Wnt/β-catenin pathway has been ...
