Now showing items 2619-2638 of 3213

    Role of PLK1 in steroid hormone signaling in breast cancer cells 

    Wierer, Michael (Date of defense: 2013-01-13)

    Steroid receptors (SRs) are hormone-induced transcription factors that regulate gene expression by their concerted actions with coregulatory proteins. Performing a quantitative mass spectrometry-based interaction screen ...

    Role of polycomb-like proteins in mouse embryonic stem cell differentiation 

    Condemi, Livia (Date of defense: 2024-03-07)

    Polycomb repressive complex (PRC) 2 is one of the key regulators of the transcriptional programs, it maintains stem cell properties and guides cell lineage specification. It is a multiprotein complex formed by a core and ...

    Role of PRC2-associated factor EPOP in mouse embryonic stem cells differentiation and early development 

    Chammas, Paul (Date of defense: 2019-11-29)

    Polycomb repressive complex 2 (PRC2) is a key epigenetic regulator of gene expression. It acts through its histone-modifying activity, as it is responsible of di- and trimethylating the tail of histone H3 on lysine 27 ...

    Role of progranulin in humoral immunity 

    Cassis, Linda (Date of defense: 2015-10-29)

    Human spleen is continually exposed to blood-borne antigens derived from autologous apoptotic cells and commensal bacteria. This chronic stimulation of the marginal zone (MZ) results in the generation of a steady-state ...

    Role of psychological and culturaly influenced risk factors on symptoms and disability for musculoskeletal disorders. CUPID study (Spain) 

    Vargas-Prada Figueroa, Sergio (Date of defense: 2014-01-24)

    This PhD thesis is based on the Spanish sample of the International “Cultural and Psychosocial Influences on Disability” (CUPID) study. This multicentre study is coordinated by Professor David Coggon at the University of ...

    Role of RanGTP and spindle assembly factors in cilia assembly and function 

    Mòdol Cano, Aitor (Date of defense: 2021-04-29)

    El cilio primario es una estructura formada por microtúbulos que sobresale de la superficie celular durante G0 teniendo una función de orgánulo sensor. La importancia del cilio es patente por las ciliopatías como la ...

    Role of Ring1B in ephitelial to mesenchimal transition, invasion and migration of mammary epithelial cells 

    Bosch Gutiérrez, Almudena (Date of defense: 2009-12-21)

    The Polycomb group (PcG) family of proteins form chromatin-modifying complexes essential for embryonic development, and stem cell renewal and are commonly deregulated in cancer. There are several reports that address the ...

    Role of the amygdala and the hippocampus in conscious perception and emotion processing in patients with drug resistant epilepsy 

    Quevedo Díaz, Marcos (Date of defense: 2017-12-21)

    Understanding the neural basis of conscious perception is still one of the central unsolved problems in neuroscience. Current theoretical models of conscious processing include the Global Workspace Theory, that proposes ...

    Role of the cellular decapping activator LSM1-7 complex in the replication of positive-strand RNA viruses 

    Galão, Rui Pedro Ribeiro (Date of defense: 2010-12-01)

    By using the ability of the positive-strand RNA ((+)RNA) virus BMV to replicate in yeast it was previously shown that subunits of the LSm1-7 ring, as well as Pat1 and Dhh1 play an essential role in the transit of the BMV ...

    Role of the endocannabinoid system in the control of the cerebellar functions 

    Cutando Ruiz, Laura (Date of defense: 2015-07-17)

    The endocannabinoid system is an endogenous neuromodulatory system widely expressed in the central nervous system. It modulates synaptic plasticity and neuronal excitability, and fine-tunes several physiological functions ...

    Role of the LILRB1 HLA class I-specific inhibitory receptor in the regulation of macrophage function 

    Baía, Diogo Nogueira de Graça (Date of defense: 2014-10-24)

    In the present work the regulatory role played by the HLA class I (HLA-I)-specific LILRB1 inhibitory receptor in human macrophages (MΦ) was addressed. In vitro differentiated monocyte-derived M1 and M2 MΦ expressed different ...

    Role of the MAP kinase Sty1 and the transcription factor Atf1 in euchromatin and heterochromatin dynamics in Schizosaccharomyces pombe 

    Fraile Beneitez, Rodrigo (Date of defense: 2021-07-23)

    Eukaryotic DNA is condensed inside the nucleus, compacted into chromatin. The structure of chromatin is dynamic, and its accessibility to cellular machinery can be altered depending on the level of chromatin compaction ...

    Role of the protein quality control system in basal and stress conditions in fission yeast 

    Marte, Luis (Date of defense: 2020-01-31)

    Proteostasis is the proper homeostasis of the concentration and the molecular structure of the proteins, which preserves the integrity of the proteome. Proteo-stasis is constantly challenged by intrinsic and extrinsic ...

    Role of the sigma-1 receptor in the pathophysiology of osteoarthritis pain 

    Carcolé Estrada, Mireia (Date of defense: 2019-12-05)

    Osteoarthritis is the most common musculoskeletal disease worldwide, characterized by degradation of the articular cartilage, chronic joint pain and disability. Currently available treatments for osteoarthritis have limited ...

    Role of the STAR proteins in early mammalian development and pluripotency 

    Dasti, Alessandro (Date of defense: 2020-01-22)

    The molecular basis that sustain embryonic stem cell (ESCs) pluripotency and their differentiation in all the types of somatic cells is subject of intensive research. Recently, the potential involvement of RNA Binding ...

    Role of the stress-dependent MAP kinase Sty1 and the transcription factor Atf1 in transcription regulation in fission yeast 

    Sansó Martínez, Miriam (Date of defense: 2010-07-02)

    In Schizosaccharomyces pombe, the MAPK pathway Sty1 is activated upon several stress situations, like osmotic and oxidative stress, stationary phase, UV radiation or heat shock. Since the modulation of gene expression is ...

    Role of the transcription factor NFAT5 in mammalian cell cycle regulation 

    Drews-Elger, Katherine (Date of defense: 2008-11-07)

    The transcription factor NFAT5/TonEBP belongs to the Rel family, which also comprises NF ÛB and NFATc proteins. NFAT5 only shares structural and functional homology with other Rel family members at the level of the DNA ...

    Role of TRPV4 channels in adverse cardiac remodelling 

    Yáñez Bisbe, Laia (Date of defense: 2022-02-25)

    Els mecanismes que determinen el desenvolupament de remodelat cardíac, tant en la seva forma adversa (característica de la insuficiència cardíaca), com adaptativa (induïda per exercici), no es coneixen en detall. Els ...

    Roles of Sox3 and Lmx 1b in early development of the inner ear 

    Khatri, Safia (Date of defense: 2009-03-23)

    En els darrers anys s'ha produït un gran avenç en l'enteniment dels mecanismes implicats en la inducció de la placoda òtica. Tanmateix, poc es coneix encara de com s'estableix un domini amb competència neural i un altre ...

    Ruptura del projecte parental i disposició dels preembrions 

    Farnós Amorós, Esther (Date of defense: 2010-05-05)

    La tesi doctoral "Ruptura del projecte parental i disposició dels preembrions" analitza els efectes del consentiment a les tècniques de reproducció assistida prestat en el marc d'un projecte parental. La tesi ofereix una ...