Universitat Pompeu Fabra
Now showing items 3090-3109 of 3213
L’estudi de la variació estructural complementa l’estudi de la variació de seqüència per revelar les complexitats de la variació fenotípica. Els gossos són l’espècie domesticada amb més variació fenotípica que existeix ...
According to estimates, over the 3.5 billion years that have elapsed since the appearance of life, the Earth has been inhabited by some 4 billion different species, of which 99.99% have already become extinct. Extinction ...
T-cell homeostasis must be tightly regulated and maintained in order to guarantee appropriate immune responses and prevent immunopathology. This maintenance depends on MHC-TCR interaction and cytokine-mediated signals among ...
The EBV has been linked to multiple human disease phenotypes and has been associated with cancers and other infections. Recently single gene analysis and genome-wide analysis studies have been exploited to uncover the human ...
Understanding how receptor-ligand interactions occur is a first step towards designing new drugs. The complete reconstruction of the binding process in a drug-receptor system provides all the physical-chemistry variables ...
Three microtubule (MT) assembly pathways participate in the assembly of the bipolar spindle: the centrosomal pathway, the augmin dependent amplification pathway and the RanGTP/chromosome dependent pathway. To form the ...
Rearrangements involving the mixed lineage leukemia gene (MLL) are found in majority of human infant leukemias (>60% of ALLs, 35% of AMLs) and are associated with dismal prognosis of these patients. They are also found in ...
Advanced societies have witnessed unprecedented socioeconomic and technological changes in the last 50 years. The growth of the service sector has transformed the class structure, and social mobility has increased for ...
The three chapters included in this dissertation aim to improve our understanding of the distance between people's desires regarding the timing and the number of children they want to have and what they finally achieve. ...
Cancer is a disease of the genome. The study of tumor genomic alterations is used to guide several precision medicine strategies, some approved and a large number under clinical development. On the other hand, the study ...
La aplicación de la radiación ionizante (RI) en ámbito médico ha llegado, sin duda, para salvar vidas. Sin embargo, hay una preocupación entre los expertos de salud pública y protección radiológica con relación al incremento ...
Los inhibidores de PARP han surgido como nuevas terapias basadas en el papel essencial de las Poly (ADP-ribosa) polimerasas PARP-1 y PARP-2 en la respuesta a daño en el DNA, explotando el efecto de las mismas en la célula ...
Aquesta tesi investiga els mecanismes de formació i evolució de gens de novo utilitzant seqüenciació massiva de transcrits complerts i de fragments protegits per ribosomes. Hem identificat milers de gens de novo en humans ...
The local translation of messenger RNAs (mRNAs) within different neuronal compartments is a prerequisite the formation of long-term memories. mRNAs are localized via active transport along microtubules, however, the ...
This thesis is focused on the nationalization of party systems in Western Europe and combines four different approaches. Despite the literature claiming that political decentralization reduces party system nationalization, ...
The purpose of this dissertation is to systematically investigate the theoretical perspective that political power derives from socioeconomic power—a fundamental tenet of both sociological theories of assimilation and ...
Background: There is evidence suggesting that body weight is associated with lung function, but results are contradictory and suffer from important limitations. We aimed to assess the association of body weight and composition ...
To ensure faithful segregation of the genetic material, cells build the mitotic spindle, a machinery made of dynamic microtubules (MTs) and MT associated proteins (MAPs). Chromosome bi-orientation is achieved through the ...
The present research is aimed at analyzing how human’s brain jointly computes cognitive and social interactions in presence of implicit social stimuli and/or in presence of socially neutral stimuli. First we analyzed the ...
