Mariotti, Marco (Date of defense: 2013-12-13)
Selenoproteins are a diverse class of proteins containing selenocysteine, the 21st aminoacid. Selenocysteine is inserted co-translationally, recoding very specific UGA codons through a dedicated ...
Segura Puimedon, Maria (Date of defense: 2012-11-20)
Williams-Beuren syndrome (WBS) is a neurodevelopmental disorder caused by the common deletion of 26-28 contiguous genes in the 7q11.23 region, which poses difficulties to the establishment of ...
Solé Morata, Neus (Date of defense: 2017-12-15)
The Y chromosome is the longest non-recombining DNA sequence of the human genome. This avoidance of recombination, together with its paternal inheritance, makes the Y chromosome a powerful tool with ...
Althammer, Sonja Daniela (Date of defense: 2012-04-27)
The recent advent of High-Throughput Sequencing (HTS) methods has triggered a revolution in gene regulation studies. Demand has never been higher to process the immense amount of emerging data to gain ...
Gigli, Elena (Date of defense: 2011-06-20)
The evolutionary history of H. neanderthalensis, interwoven with that of H. sapiens, has always fascinated the scientific world. Recent adavncess in paleogenetics shedds new light on the phylogenetic ...
Ullrich, Sebastian (Date of defense: 2018-12-19)
Gene regulation orchestrates the development of different cell types and organs from the same genetic blueprint. While the basic mode of gene regulation is driven by transcription factors, there are a ...
Demidov, German (Date of defense: 2019-12-13)
Germline copy-number variants (CNVs), as well as somatic copy-number alterations (CNAs), play an important role in many phenotypic traits, including genetic diseases and cancer. Next Generation Sequencing ...
Mendizábal Eceizabarrena, Isabel (Date of defense: 2012-07-27)
The human colonization of worldwide landmasses occurred through complex patterns of dispersal and admixture. At the same time, the survival in the different areas of the world depended on the adaptation ...
Ylla Bou, Guillem (Date of defense: 2018-01-24)
The evolutionary success of insects was particularly shaped by the innovation of the metamorphosis, especially by the transition from hemimetaboly to holometaboly. The mechanisms underlying this ...
Laurie, Steven (Date of defense: 2013-07-25)
This thesis comprises comparative genomics analyses primarily focussing on the evolution of mammalian proteins. We concentrate on three species of direct relevance as model organisms, for which high ...