Espeso Gil, Sergio (Date of defense: 2016-12-05)
El reguloma està constituït per un sistema complex de factors que controlen el fenotip molecular de la cèl·lula, que al seu torn està influenciada pel medi ambient. Qualsevol pertorbació pot desencadenar ...
Corrionero Saiz, Ana (Date of defense: 2010-12-16)
Alternative splicing provides the cell the ability to generate, from a single gene, multiple protein isoforms, sometimes with different or even antagonistic functions. This process is tightly regulated ...
Carreté Muñoz, Laia (Date of defense: 2018-01-23)
Infections caused by pathogenic fungi are becoming an increasingly serious threat for human health. Pathogenic fungi such as Candida glabrata or Candida albicans, belong to phylogenetically distinct ...
Toll i Riera, Macarena (Date of defense: 2012-03-28)
Actualment, degut a la disponibilitat d’un gran nombre de genomes seqüenciats, el camp de la genòmica comparativa està experimentant grans avenços. Ara són possibles una àmplia gama d’estudis que fins ...
Santesmasses Ruiz, Didac (Date of defense: 2016-12-12)
La selenocïsteina és coneguda com a l'aminoàcid 21. Les selenoproteïnes incorporen selenocïsteina en resposta a codons UGA específics mitjançant un mecanisme de recodificació, el qual és present en els ...
Vujatovic, Olivera (Date of defense: 2012-07-27)
We did functional characterisation of Drosophila melanogaster linker histone, dH1. In the mutant state for this protein, we observed structural changes in polytene chromosomes chromocenter and nucleoli ...
Piñero González, Janet (Date of defense: 2015-12-17)
In the last two decades, the volume and variety of biomedical data has dramatically increased. The data is heterogeneous and scattered across many resources. This produces bottlenecks in the analysis ...
Jhanwar, Shalu (Date of defense: 2017-01-11)
Epigenetics provides a plausible link between the environment and changes in gene expression that might contribute to disease phenotypes. The main goal of the thesis is to study epigenomic variability ...
Puigdevall Costa, Pau (Date of defense: 2019-01-17)
Understanding the molecular basis of human inherited disease is a challenging task due to the complexity of mapping the genotype to the phenotype. The study of diseases running in families has shown ...
Reina Castillón, Judith (Date of defense: 2017-10-24)
Somatic genetic mosaicism can be present both in healthy individuals but also in subjects with certain conditions as ageing or cancer. Its detection by SNP array in blood can be used as biomarker of ...