Schroeder, Michael Philipp (Date of defense: 2014-11-21)
Cancer is a complex disease caused by somatic alterations of the genome and epigenome in tumor cells. Increased investments and cheaper access to various technologies have built momentum for the generation ...
Arnedo Pac, Claudia Rosario (Date of defense: 2022-12-15)
Sequencing of cancer genomes reveals the story of mutational events shaping the distribution of somatic mutations across the nucleotide sequence. A particular pattern of such distribution, mutational ...
Rubio Pérez, Carlota (Date of defense: 2017-11-28)
Cancer is a disease of the genome. The study of tumor genomic alterations is used to guide several precision medicine strategies, some approved and a large number under clinical development. On the other ...
Pich Roselló, Oriol (Date of defense: 2021-03-24)
Cells of our body are constantly exposed to events that can create lesions in the DNA. If unremoved by the DNA repair mechanisms, the lesion may lead to a mutational event. Some of these events might ...
Sentís Carreras, Inés (Date of defense: 2021-01-22)
Acute lymphoblastic leukemia (ALL) is a blood cancer characterized by a high proliferation and maturation arrest of the lymphoid precursors which can either be from B or T-cell lineage. In adult patients, ...
Bonet Giner, Jose (Date of defense: 2022-06-03)
Sequencing technologies have recently evolved and generated large amounts of data. These datasets have had significant impacts in the cancer field and the detection of damage and repair mechanisms. ...
Frigola Rissech, Joan (Date of defense: 2020-03-13)
The rate at which mutations accumulate along the genome is not uniform but influenced by factors such as chromatin compactness, replication time or transcription. Most of these factors create mutational ...