Mostrando ítems 1-6 de 6
Di Stefano, Bruno (Fecha de defensa: 2014-06-05)
One of the major goals of current stem cell research is understanding the mechanism of somatic cell reprogramming by Oct4, Sox2, Klf4 and Myc (OSKM) into induced pluripotent stem cells (iPSCs). However, ...
Rapino, Francesca (Fecha de defensa: 2013-12-02)
B-cell malignancies encompass a wide variety of distinct diseases including Non Hodgkin lymphoma (NHL) and leukemia. Currently, chemotherapy, radiation and anti-CD20 antibody treatment are the mainstays ...
Plana Carmona, Marcos (Fecha de defensa: 2021-03-17)
Continuous C/EBPa expression converts B cells into macrophages while its transient upregulation before the Yamanaka factors yields highly efficient iPSC reprogramming. C/EBP members regulate Il6 ...
Andrés Aguayo, Luisa de (Fecha de defensa: 2017-05-05)
The life-long production of blood cells is enabled by hematopoietic stem and progenitor cells (HSPC) residing in the bone marrow. An understanding of the genes that control how HSPCs work to sustain the ...
Torcal Garcia, Guillem (Fecha de defensa: 2022-02-10)
Lineage-instructive transcription factors orchestrate cell fate decisions by regulating gene expression programs. However, how their function is regulated throughout development is poorly understood. ...
Di Tullio, Alessandro (Fecha de defensa: 2012-07-13)
Our earlier work has shown that pre-B cells can be converted into macrophages by the transcription factor C/EBPα at very high frequencies and also that a clonal pre-B cell line with an inducible form ...