Garriga Nogales, Edgar (Date of defense: 2022-02-15)
In these days of significant changes and the rapid evolution of technology, the amount of datascience has to deal with the growth incredibly fast, and the size of data could be prohibitive.Multiple ...
Prieto Barja, Pablo (Date of defense: 2017-01-12)
In this PhD I have used NGS technologies in different organisms and scenarios such as in ENCODE, comparing the conservation and evolution of long non-coding RNA sequences between human and mouse, using ...
Floden, Evan (Date of defense: 2018-11-30)
A multiple sequence alignment (MSA) provides a description of the relationship between biological sequences where columns represent a shared ancestry through an implied set of evolutionary events. The ...
Chatzou, Maria (Date of defense: 2016-11-07)
One of the main and most recent challenges of modern biology is to keep-up with growing amount of biological data coming from next generation sequencing technologies. Keeping up with the growing volumes ...
Baltzis, Athanasios (Date of defense: 2023-03-20)
Recent advances in deep learning techniques have revolutionised protein structure modelling. Since AlphaFold2’s release, a set of tools have now become available to predict native-like structures at ...
Mansouri, Leila (Date of defense: 2023-03-27)
El continuo aumento de los proyectos de producción de datos genómicos a gran escala, como el "Earth BioGenome Project" (Lewin et al., 2018), pone los métodos de análisis de datos bajo una presión sin ...
Chang, Jia-Ming (Date of defense: 2013-07-25)
Most evolutionary analyses are based upon pre-estimated multiple sequence alignment models. From a computational point of view, it is too complex to estimate a correct alignment, as it is to derive a ...
Espinosa-Carrasco, José (Date of defense: 2016-11-08)
New high-throughput behavioral systems enable the recording of continuous behavioral sequences with an unprecedented richness of signals and a deep temporal resolution. Automated systems offer neuroscience ...
Bussotti, Giovanni (Date of defense: 2013-01-23)
In recent years there has been a growing interest in the field of non-coding RNA. This surge is a direct consequence of the discovery of a huge number of new non-coding genes, and of the finding that ...
Kemena, Carsten (Date of defense: 2012-12-12)
Sequence alignment is one of the basic methods to compare biological sequences and the cornerstone of a wide range of different analyses. Due to this privileged position at the beginning of many studies ...