Althammer, Sonja Daniela (Date of defense: 2012-04-27)
The recent advent of High-Throughput Sequencing (HTS) methods has triggered a revolution in gene regulation studies. Demand has never been higher to process the immense amount of emerging data to gain ...
Toll i Riera, Macarena (Date of defense: 2012-03-28)
Actualment, degut a la disponibilitat d’un gran nombre de genomes seqüenciats, el camp de la genòmica comparativa està experimentant grans avenços. Ara són possibles una àmplia gama d’estudis que fins ...
Pagès Pinós, Amadís (Date of defense: 2016-10-27)
El processament de les cadenes d’àcids ribonucleics (ARN) és un mecanisme mol·lecular crucial gràcies al qual els precursors delsARN missatgers es converteixen en ARN missatgers madurs. L’exemple més ...
Singh, Babita (Date of defense: 2017-05-11)
RNA processing and their alterations are determinant to understand normal and disease cell phenotypes. In particular, specific alterations in the RNA processing of genes has been linked to widely accepted ...
González-Vallinas Rostes, Juan (Date of defense: 2013-09-09)
High Throughput Sequencing technologies (HTS) are becoming the standard in genomic regulation analysis. During my thesis I developed software for the analysis of HTS data. Through collaborations with ...
Plass Pórtulas, Mireya (Date of defense: 2011-07-12)
L’splicing és el mecanisme pel qual els introns són eliminats del pre-mRNA per generar un trànscrit madur. Aquest procés és dut a terme per un complex macromolecular anomenat spliceosoma i requereix el ...
Agirre Ortiz de Guzmán, Eneritz (Date of defense: 2013-06-21)
Generalment s'ha pensat que la regulació de l'splicing alternatiu està controlada principalment per la interacció entre els factors reguladors de l'splicing i la taxa d'elongació de la ARN polimerasa ...
Kremsky, Isaac Jacob (Date of defense: 2015-07-14)
Proteins that bind to DNA or RNA are both known to influence alternative splicing. However, there has not been so far a systematic experimental exploration of the relationship between these factors ...
Trincado Alonso, Juan Luis (Date of defense: 2019-01-28)
The following thesis tries to answer the question of wheter RNA processing alterations are informative for the clinical management of cancer patients. For this, the work is focused on solve two main ...