Demidov, German (Date of defense: 2019-12-13)
Germline copy-number variants (CNVs), as well as somatic copy-number alterations (CNAs), play an important role in many phenotypic traits, including genetic diseases and cancer. Next Generation Sequencing ...
Espeso Gil, Sergio (Date of defense: 2016-12-05)
El reguloma està constituït per un sistema complex de factors que controlen el fenotip molecular de la cèl·lula, que al seu torn està influenciada pel medi ambient. Qualsevol pertorbació pot desencadenar ...
Jhanwar, Shalu (Date of defense: 2017-01-11)
Epigenetics provides a plausible link between the environment and changes in gene expression that might contribute to disease phenotypes. The main goal of the thesis is to study epigenomic variability ...
Muyas Remolar, Francesc (Date of defense: 2019-12-20)
The rapid development of high-throughput sequencing technologies pushed forward the fields of medical genomics and precision medicine, creating many new applications for diagnostics and clinical studies ...
Zapata Ortiz, Luis (Date of defense: 2016-10-05)
Tumors are composed of fast-growing cells that become malignant under selection of biological functions needed for cancer development. In this thesis, I intend to uncover the basic evolutionary principles ...
Sušak, Hana (Date of defense: 2017-12-05)
Els distints projectes internacionals de seqüenciació de càncer duts a terme en els últims anys han generat catàlegs complets d’alteracions trobades en els genomes tumorals, així com informació de ...