Martí Solano, Maria (Date of defense: 2015-02-10)
La caracterització de diversos fàrmacs capaços d’unir-se a receptors associats a proteïnes G (GPCR)s ha revelat que els seus mecanismes d’acció no eren tan simples com es creia. Primer, l’anàlisi de la ...
Księżopolska, Ewa (Date of defense: 2021-07-05)
This project was set out to broaden our knowledge of the processes driving the emergence of antifungal drug resistance in an opportunistic yeast pathogen Candida glabrata. More precisely, we sought to ...
Almeida Cotrim, Bruno (Date of defense: 2011-01-10)
Obesity constitutes a problem whose manifestations have consequences in almost every field of the medicine and nowadays there is a lack of pharmacological therapy alternatives for its long term ...
An, Weiteng (Date of defense: 2021-04-14)
Peptide-based vaccines have raised as an attractive alternative strategy to overcome many of the limitations of conventional vaccines. Some drawbacks for an optimal immune response in vivo are, a poor ...
Gallo, María (Date of defense: 2021-07-22)
This thesis focuses on one of the biggest challenges facing drug discovery field: the efficient targeted delivery of therapeutic compounds, and how cell-penetrating peptides (CPPs) acting as drug delivery ...
Falaguera Mata, Maria José (Date of defense: 2022-04-26)
Systems pharmacology is the discipline that studies the so-called ‘pharmacological space’ with a holistic and network-based perspective. Its challenge is to shed light on the astonishingly sophisticated ...
Such Sanmartin, Gerard (Date of defense: 2010-01-28)
Human growth hormone (GH) participates in human longitudinal growth, lipid and carbohydrate metabolism, and comprises a remarkably number of proteins with similar sequences, generated either genetically ...
Pinto Gil, Kevin (Date of defense: 2020-01-31)
Despite the investment of vast amounts of money over the last decades, drug discovery and development remains an inefficient process, which can be stopped at different steps, leading to the loss of ...
Szabó, Viktória (Date of defense: 2019-03-13)
The demographic shift toward an aging population is increasing the burden of public health. On average, a person of 70 years can combine the intake of up to seven medications. The administration of ...
Vila Rodríguez, Javier (Date of defense: 2016-11-25)
Introducción: Con el fin de mejorar los métodos de evaluación de la exposición a campos electromagnéticos, desarrollamos un nuevo método basado en fuentes de exposición en lugar de códigos de ocupación. ...