Mestre-Farrera, Aida (Date of defense: 2020-02-27)
Tumors are complex tissues composed by multiple cell types, such as cancer associated fibroblasts (CAFs), that facilitate the invasive behavior of tumor cells. When we examined their nutrient requirements, ...
Olivera-Salguero, Rubén (Date of defense: 2019-07-19)
Snail1 is the master regulator of the Epithelial-to-Mesenchymal Transition (EMT) and is also crucial for fibroblast activation upon TGFβ signaling. In cancer, Snail1 expression in primary tumors correlates ...
Batlle Gómez, Raquel (Date of defense: 2011-12-19)
The Snail1 transcriptional repressor is a key factor responsible in triggering epithelial to mesenchymal transition. Although Snail1 is widely expressed in early development, it is limited in adult ...
Viñas Castells, Rosa (Date of defense: 2013-05-24)
Epithelial to mesenchymal transition (EMT) is a process by which epithelial cells acquire a mesenchymal phenotype. It is characterized by the down-regulation of the adherens junction protein E-cadherin, ...
Millanes Romero, Alba (Date of defense: 2014-01-21)
Although heterochromatin is enriched with repressive traits, it is actively transcribed, giving rise to large amounts of non-coding RNAs. These transcripts are responsible for the formation and ...
Cabrerizo Granados, David (Date of defense: 2020-11-30)
Snail1 is a transcriptional factor with a great relevance in tumor development as it is required for epithelial to mesenchymal transition and activation of cancer-associated fibroblasts (CAF). In this ...
Alba Castellón, Lorena (Date of defense: 2016-02-17)
Snail transcription factor 1 triggers epithelial to mesenchymal transition. In cancer, this process provides tumoral epithelial cells with invasive characteristics. In this thesis, we demonstrated that ...
Gonzàlez Busqué, Núria (Date of defense: 2017-09-18)
Snail1 transcription factor is the key inducer of epithelial-to-mesenchymal transition (EMT). Here, we describe a novel role for Snail1 on the regulation of telomere integrity and transcription as well ...
Bruch Oms, Marina (Date of defense: 2022-12-12)
Tumors are complex masses composed by multiple cell types, such as cancer associated fibroblasts (CAFs) and macrophages, that interact with each other promoting the tumor progression. Snail1 is a ...