Arcas Mantas, Aida (Date of defense: 2013-04-25)
The DNA Damage response is a crucial signaling network that preserves genome integrity. This network is an ensemble of distinct but often overlapping sub-networks, where participating components exert ...
García Pérez, Raquel (Date of defense: 2019-01-29)
The evolution of the human phenotype involved gene regulatory innovations. Comparative functional epigenomic studies are a powerful tool with potential to shed light on many long-standing questions ...
Capella Gutiérrez, Salvador Jesús (Date of defense: 2012-11-16)
Phylogenomics is a biological discipline which can be understood as the intersection of the fields of genomics and evolution. Its main focuses are the analyses of genomes through the evolutionary lens ...
Platania, Leonardo (Date of defense: 2023-10-11)
The South Pacific is an intriguing region for studying evolutionary biology, presenting an exceptional diversity and complex geological and environmental characteristics. New Caledonia, in particular, ...
Mantica, Federica (Date of defense: 2023-05-11)
Regulated Gene Expression (rGE) and Alternative Splicing (rAS) are two of the main mechanisms contributing to tissue-phenotypic diversity within and between species. In this thesis, we aim at characterizing ...
Pittis, Alexandros (Date of defense: 2016-10-14)
The origin of eukaryotic compartmentalization stands as a major conundrum in biology. Current evidence indicates that the last eukaryotic common ancestor (LECA) already possessed many eukaryotic hallmarks, ...
Carvalho, Tiago Loureiro de (Date of defense: 2016-01-21)
Genetic variation in humans and the great apes has been amply explored using a wide variety of markers, among them tandem repeats (TRs). Because of the nature of TRs, highly variable in length due to ...
Torres Méndez, Antonio (Date of defense: 2020-02-28)
Post-transcriptional networks control multiple aspects of neuronal biology and their deregulation has been associated with human neurological disorders. This thesis focuses on regulation at the level ...
López Valenzuela, María (Date of defense: 2015-01-15)
MicroRNAs (miRNAs) are major contributors to phenotypic diversity and have a demonstrated role in evolution. We performed an analysis on how miRNA nucleotide substitutions may have contributed to human ...
Verd Fernández, Berta (Date of defense: 2016-01-21)
During insect development segments either form sequentially (short-germband) or simultaneously (long-germband) . The gap genes comprise the first zygotic regulatory layer of the segmentation gene ...