Estudio de la rigidez arterial en arteria carótida y depósito tisular de hierro mediante resonancia magnética: relación con los factores de riesgo asociados al síndrome metabólico

Abstract

The aim is to demonstrate the utility of magnetic resonance (MR) for identifying subclinical changes associated with the metabolic syndrome (MS) that contribute to increased cardiometabolic risk. The effect of MS on arterial stiffness and tissue iron load were evaluated using MR in subjects with the MS and control subjects. Arterial stiffness was higher in subjects with MS than in those without. The components contributing independently to an increased pulse wave velocity were hypertension and hypertriglyceridemia. Increased iron concentration was significantly detected at the liver and brain in obese subjects. Obesity-associated brain iron overload was correlated with worse cognitive performance. Obesity and insulin resistance were found as the main factors that contribute to tissue iron deposition. In conclusion, this thesis demonstrates the utility of MR to evaluate subclinical risk changes associated with the MS in subjects without diabetes or ischemic disease

L'objectiu general consisteix en posar de manifest la utilitat de la ressonància magnètica (RM) per identificar canvis subclínics associats a la síndrome metabòlica (SM)i que contribueixen a l'increment del risc cardiometabòlic. Es va avaluar l'efecte de la SM sobre la rigidesa arterial i el dipósit de ferro tisular mitjançant RM en individus amb SM i controls. Es va observar un augment de la rigidesa arterial associada a la SM, essent l’hipertensió i hipertrigliceridèmia els principals components desencadenants. També es va observar un augment del dipòsit de ferro hepàtic i cerebral associat a l’obesitat. La sobrecàrrega de ferro cerebral es va correlacionar amb pitjors puntuacions del rendiment cognitiu. Els principals factors precursors de dipòsit de ferro van ser la insulino-resistencia i l'obesitat. En conclusió, es posa de manifest l’utilitat de la RM per avaluar canvis subclínics associats a la SM en individus sense antecedents de diabetis o malaltia vascular isquèmica