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Browsing Departament de Biomedicina by Date of defense

Now showing items 21-31 of 31

    Regulació i funció en resposta a diferents tipus d’estrès de la CaMKK Ckk2 

    Martin Ramos, Edgar (Date of defense: 2021-04-26)

    Les proteïnes de la família de les CaM quinases (CAMK en anglès), l’activitat de les quals és dependent del complex calci-calmodulina, estan implicada en funcions cel·lulars com la regulació de l’expressió gènica, la ...

    Involvement of Foxp2 in the alterations of the basal ganglia circuitry in Huntington’s Disease 

    Rodríguez Urgellés, Ened (Date of defense: 2022-01-20)

    Huntington’s Disease (HD) is an autosomal dominant inherited neurodegenerative disorder characterized by motor, psychiatric, and cognitive manifestations. The disease is caused by an unstable expansion of the CAG trinucleotide ...

    El paper de p27 a la regulació de la via de Notch 

    Durán Rodríguez, Rodrigo (Date of defense: 2022-01-28)

    Partint dels resultats previs obtinguts per aquest grup d’investigació, es planteja la següent hipòtesi de treball: “La proteïna p27 és un regulador de la via de Notch. Aquesta regulació es realitzaria, principalment, ...

    Regulation of synthesis, transport and accumulation of lipids in Lipid droplets by Acetyl-CoA carboxylase and Caveolins. How cells accumulate lipids but reduce lipotoxicity 

    Morales Paytuví, Frederic (Date of defense: 2022-02-04)

    The following sections of the thesis are divided in two parts corresponding with the two projects conducted, whose objectives are stated below. 1. Caveolin in the endoplasmic reticulum During the last years, the ...

    Aberrant TIMP-1 regulation in tumor-associated fibroblasts by the TGF-β1/SMAD3 pathway in lung cancer: implications in tumor progression and resistance to antifibrotic therapies 

    Duch Gili, Paula (Date of defense: 2022-03-14)

    Increased expression of TIMP-1 is associated with poor prognosis in virtually all cancer types, including lung cancer. However, how TIMP-1 is regulated in lung cancer and how it drives tumor progression is poorly defined. ...

    Mitochondrial dynamics and quality control mechanisms in Huntington's disease 

    López Molina, Laura (Date of defense: 2022-06-17)

    [spa] La enfermedad de Huntington (EH) es una enfermedad neurodegenerativa hereditaria causada por la mutación de la huntingtina (mHtt) que ocasiona síntomas motores, cognitivos y psiquiátricos. La característica ...

    Comparative study of nanocarriers targeted to different transport pathways into and across the endothelium for brain delivery of therapeutic enzymes 

    Loeck, Maximilian (Date of defense: 2022-09-16)

    [eng] The blood-brain barrier (BBB) is a major obstacle for the treatment of neurological diseases such as common Parkinson’s disease or rare lysosomal storage disorders (LSDs). LSDs are characterised by deficiency of ...

    Microphthalmia-associated Transcription Factor function and regulation in KIT oncogenic pathologies 

    Proaño Pérez, Elizabeth (Date of defense: 2022-11-30)

    [eng] KIT (CD117) is a tyrosine kinase receptor expressed in hematopoietic progenitors, melanocytes, germ cells, mast cells, and interstitial cells of Cajal (ICC) of the digestive tract. KIT gain-of-function mutations have ...

    Effects of human serum albumin on TNFα-induced cell death and mitochondrial dysfunction in the liver cells 

    Duran Güell, Marta (Date of defense: 2023-04-12)

    [eng] Albumin exerts pleiotropic actions beyond its oncotic power, which include binding, transport and detoxification of endogenous and exogenous molecules, antioxidant activity and the modulation of immune and inflammatory ...

    Evaluación funcional del péptido EAR-20 como posible agonista de los receptores ionotrópicos de glutamato de tipo NMDA 

    García Díaz, Roberto (Date of defense: 2023-05-26)

    [spa] Debido a la importancia de la modulación del NMDAR, en el grupo de investigación de proteínas (GRIP) se han diseñado una serie de péptidos derivados de la Conantokina-G (Con-G), un péptido antagonista de los NMDARs, ...

    Noves estratègies terapèutiques contra la resposta a l’estrès replicatiu en el càncer colorectal 

    Unzueta Payeras, Fernando (Date of defense: 2023-07-28)

    [cat] El nostre laboratori està centrat en l’estudi de la resposta a l’estrès replicatiu, ja que aquest estrès està relacionat amb la tumorigènesi i la seva resposta és un mecanisme fonamental per preservar l’estabilitat ...