Mostrando ítems 1-10 de 18
Yoldi, Guillermo (Fecha de defensa: 2018-10-23)
The discovery that RANK signaling mediates the protumorigenic role of progesterone in the mammary gland and its association with poor prognosis in breast cancer has opened the possibility of using RANKL ...
Zuazo Gaztelu, Iratxe (Fecha de defensa: 2018-11-23)
Tumor progression is a complex conundrum of events that involve not only tumor cells, but also their surrounding microenvironment. Accounting to the natural dependency of tumors on angiogenesis, its ...
Simón Extremera, Pilar (Fecha de defensa: 2017-05-12)
El carcinoma escamoso (SCC) es el segundo tumor de piel más frecuente en humanos caucásicos. Estudios recientes demuestran que el crecimiento tumoral es mantenido por una población de células tumorales, ...
Domostegui Fernández, Ana (Fecha de defensa: 2019-12-05)
The oncogene MYC is altered and its expression is deregulated in up to 70% of human cancers, including B cell neoplasms. Earlier studies in a mouse model of Eμ-MYC-driven B-cell lymphomas reported that ...
Méndiz Manero, Mª Victoria (Fecha de defensa: 2022-09-16)
[eng] I have used the brain tumours that originate in Drosophila larvae upon depletion of the brain tumor (brat) gene as a model to study neoplastic malignant growth. I have used genetic analysis to ...
Balcells Nadal, Cristina (Fecha de defensa: 2019-12-19)
Metastasis and drug resistance represent the two main causes of therapeutic failure in oncology. In the present dissertation, the interplay between them has been interrogated using metabolomics, systems ...
Arroba Hidalgo, Ester (Fecha de defensa: 2021-02-10)
The human leukocyte antigen-G (HLA-G) is a non-classic MHC class I molecule. It is called “non-classic” because it differs from classic MHC class I molecules due to its very low amount of polymorphism ...
Riaño Canalias, Ferran (Fecha de defensa: 2017-09-29)
Ribosome biogenesis is one of the most energy consuming anabolic processes in a cell, required for the generation of the translational machinery to grow and proliferate. Moreover, this process necessitates ...
Gutierrez Prat, Núria (Fecha de defensa: 2018-10-03)
Cells often need to respond to damaging internal and external stimuli. One of the pathways that is frequently activated by stress stimuli involves activation of the kinase p38alpha, which can phosphorylate ...
Sostoa Pomés, Jana de (Fecha de defensa: 2019-05-31)
Oncolytic virus (OV)-based therapies have an emerging role in the treatment of solid tumors, involving both direct cell lysis and immunogenic cell death. Nonetheless, tumor- associated stroma limits the ...