Ferrández Roldán, Alfonso (Date of defense: 2021-02-22)
The bloom of genomic data has revealed a vast amount of gene losses across all life kingdoms. However, the impact of gene loss on the evolution of the mechanisms of embryo development remains an important ...
Navas Pérez, Enrique (Date of defense: 2017-07-28)
Uno de los mecanismos genéticos que facilitan la innovación evolutiva es la formación de nuevos genes. De entre los procesos que permiten generar nuevos genes, la domesticación molecular de genes ...
Burguera Hernández, Demian (Date of defense: 2017-09-22)
In the present work, we studied the evolution of alternative splicing (AS) from different perspectives. First, we performed a preliminary analysis where we identified alternative exons with tissue-specific ...
Herrera Úbeda, Carlos (Date of defense: 2019-12-16)
In this thesis we have covered the importance of finding underlying conservation events to better understand the regulatory mechanisms of important development orchestrators like the Hox cluster. As an ...
Pi Roig, Aina (Date of defense: 2018-04-06)
Tbx5 is a transcription factor expressed in the developing eyes, heart and upper limbs. Mutations in human TBX5 cause Holt-Oram syndrome (HOS), a condition characterised by heart and upper limb ...