Departament de Genètica, Microbiologia i Estadística: Enviaments recents
Ara mostrant els elements 41-60 de 116
The evolutionary history of shearwaters: genomic analyses to resolve a radiation of pelagic seabrids
How populations differentiate and become new species is a foundational question to the field of evolutionary biology and has important implications for the generation of both local and global patterns of species-level ...
Bioreduction of iron (hydr)oxides from mine tailings under marine conditions
Mining industry faces environmental problems concerning waste management. Given the environmental issues associated with storage of mine wastes on land, one disposal option that has gained attraction is submarine tailings ...
De la genómica a la modelización: estudios poblacionales a nivel individual en peces litorales del Mediterráneo occidental
La conectividad y la adaptación local son dos fuerzas evolutivas contrastantes que influyen en la estructura poblacional. Debido a su complejo ciclo de vida, las especies de peces marinos tienden a estructurarse en ...
Seqüenciació massiva aplicada a l'epidemiologia d'aigües residuals i a la caracterització de viromes
L’objectiu principal de la present tesi doctoral ha estat l’optimització i aplicació de procediments basats en la seqüenciació massiva per a la descripció del viroma associat a l’aigua residual i a altres mostres d’interès ...
Deconstruction of the cardiopharyngeal gene regulatory network in appendicularians, a paradigmatic study of Oikopleura dioica as an evolutionary knockout model
The bloom of genomic data has revealed a vast amount of gene losses across all life kingdoms. However, the impact of gene loss on the evolution of the mechanisms of embryo development remains an important challenge. In ...
Genetic and epigenetic signatures of attention-deficit/hyperactivity disorder
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental, complex and highly heritable disorder characterised by age-inappropriate symptoms of inattention, impulsivity and hyperactivity that impair the daily ...
Genètica i epigenètica de les addiccions i trastorns comòrbids
Aquesta Tesi té com a objectiu principal contribuir a l’estudi i a la identificació de factors genètics i epigenètics de susceptibilitat a les addiccions i a trastorns comòrbids, tant en humans com en models animals. Els ...
Study of the components that determine the applicability of pathogenicity predictors in the clinical setting
The translation of Next Generation Sequencing (NGS) technologies from the research field to the clinical setting and, specifically, the results obtained in terms of diagnostic yield remain far from expected. This situation ...
Nuevos aspectos de la regulación de la virulencia en cepas enteroagregativas de Escherichia coli
En el momento del inicio de esta tesis doctoral, nuestro grupo de investigación, analizando el genoma de la cepa enteroagregativa E. coli 042 pudo comprobar que, además de los genes hha e ydgT (presentes en la mayoría de ...
Epidemiological study of aromatase inhibitors in women diagnosed with breast cancer: evaluation and management of secondary effects
Aromatase inhibitors (AI) are one of the main therapies to treat estrogen-receptor positive breast cancer. AI use is associated with several side effects that affects patient’s quality of life and reduces treatment adherence. ...
Study of disseminated high-risk neuroblastoma in the bone marrow niche; from microenvironmental modelling to therapeutic targeting
Neuroblastoma (NB) is the most common extracraneal solid tumor diagnosed in the first 5 years of childhood and accounts for approximately 15% of all pediatric cancer-related deaths. At the time of diagnosis, about half of ...
Novel therapeutic approaches against Head and Neck Squamous Cell Carcinoma
Head and neck squamous cell carcinoma (HNSCC) is usually diagnosed in advanced stages. The treatment has not changed much on the last decades, being limited to surgery followed by radiotherapy and/or chemotherapy [mainly ...
Quantitative proteomic approaches for the characterization of bacterial wilt resistance mechanisms in tomato. lnsights on the role of P69 subtilisin-like proteases in defense
The plant pathogen Ralstonia solanacearum is the causal agent of the devastating disease known as bacterial wilt. This disease affects more than 200 plant species in over 50 families, including economically important crops ...
Sea turtle conservation: genetics and genomics for a better management
Conservation actions aim to preserve and recover animal and plant species using in-situ or ex- situ strategies. The first, aims to protect and sustain populations in their natural habitat, the second are implemented when ...
Targeting the TGF-beta pathway of cancer-associated fibroblasts in colorectal cancer metastasis
Colorectal cancer (CRC) is the second-highest cause for cancer-related mortality worldwide. Patients suffering from CRC generally don’t die from primary tumours but rather from metastasis, for which there are no effective ...
Characterization of emerging novel human astrovirus: form bedside to bench
Novel human astrovirus (HAstV) are enteric virus belonging to the Astroviridae family and were discovered 10 years ago by high-throughput sequencing. They are divided in two different clades, the HAstV-MLB including 3 ...
Autonomous and non-autonomous regulation on planarian growth and regeneration: Smed-bls, canonical Wnt signalling and Fox family
Development requires an increment of cell growth and cell number, concomitant to a tightly control of cell differentiation. Thanks to cell communication, cells can be spatiotemporal patterned to acquire the required fate. ...
Genómica de la adaptación en artrópodos: estudio del sistema quimiosensorial y de la radiación del género Dysdera (Araneae) en Canarias
Los artrópodos, durante su historia evolutiva, han colonizado múltiples y diversos hábitats, incluyendo eventos de terrestrialización independientes en los distintos subfilos, e implicando en algunas ocasiones radiaciones ...
Desarrollo y utilización de herramientas bioinformáticas en el estudio de datos de secuenciación masiva: Análisis genómicos en arácnidos.
Encontramos una gran cantidad de información genómica en bases de datos para numerosos organismos pero existe un sesgo hacia ciertos grupos taxonómicos por el interés económico, social o sanitario. Los avances y el ...
Conservation of different mechanisms of Hox cluster regulation within chordates
In this thesis we have covered the importance of finding underlying conservation events to better understand the regulatory mechanisms of important development orchestrators like the Hox cluster. As an example of these ...
