Browsing Facultat de Medicina i Ciències de la Salut by Subject "616.8"

Intraoperative neurophysiological monitoring through pedicle screw stimulation

Boyadjis, Melanie (Date of defense: 2021-06-04)

OBJECTIVES: Study the interdependence between stimulus duration and stimulus strength, to observe if by changing the stimulus duration, the current threshold levels will also change during pedicle screw stimulation. Then ...

Investigations in animal models of anti-NMDAR encephalitis

García Serra, Anna (Date of defense: 2021-09-14)

[eng] BACKGROUND: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a neuronal antibody-mediated disease that associates with prominent neuropsychiatric symptoms and predominantly affects women of childbearing ...

Magnetic resonance imaging, cognition, and sex differences in Parkinson’s disease with REM sleep behavior disorder

Oltra González, Javier (Date of defense: 2022-10-28)

[eng] INTRODUCTION: This doctoral thesis is centered on Parkinson’s disease (PD) with rapid eye movement sleep behavior disorder (RBD) as a clinical subtype. Characterizing subtypes is one of the main ongoing objectives ...

Mechanisms and modulation of cortical rhythms and complexity

Barbero Castillo, Almudena (Date of defense: 2020-07-17)

Throughout various brain states, billions of neurons interact resulting in a variety of cortical rhythms accompanied by switches between behavioral states (Gervasoni et al., 2004). As a result of the specific (1) ...

Microglial implication in Parkinson's Disease: studying functional and morphological changes occurring in LRRK2 microglia during PD pathophysiology using a stem cell derived human model

Blasco Agell, Lucas (Date of defense: 2021-11-25)

[eng] Parkinson’s disease (PD) is an incurable neurodegenerative disease characterized by the loss of neuromelanin (NM)-containing dopamine neurons in Substantia Nigra pars compacta (SNpc) and accumulation of insoluble ...

Myotonic Dystrophy Type 1: the heterogeneity of a complex disease in a global research approach

Ballester López, Alfonsina (Date of defense: 2020-12-18)

Myotonic Dystrophy Type 1 (DM1) is a complex disease with a dominant autosomic inheritance caused by a CTG expansion at the end of the DMPK gene. This expansion is very unstable and it is known that is correlated with the ...

Neurobiological mechanisms involved in the antidepressant and psychotomimetic effects of NMDA receptor antagonists: role of the GluN2C subunit

Tarrés Gatius, Mireia (Date of defense: 2019-12-17)

Sub-anesthetic doses of ketamine evoke rapid and persistent antidepressant effects in treatment-resistant depressed patients through still poorly-known mechanisms. Ketamine also evokes transient psychotomimetic effects, ...

NMDA receptor mutations associated with neurodevelopmental disorders: pathophysiological impact and personalized pharmacotherapy

Santos Gómez, Ana (Date of defense: 2021-11-26)

[spa] Los receptores ionotrópicos de tipo N-metil-D-aspartato (NMDAR) son canales iónicos activados por glutamato que juegan un papel clave en la fisiología neuronal. Los avances en la secuenciación masiva han identificado ...

Noves aproximacions diagnòstiques a la paràlisi supranuclear progressiva: biomarcadors clínics, en líquid cefaloraquidi i de ressonància magnètica

Painous Martí, Cèlia (Date of defense: 2023-07-13)

[cat] La paràlisi supranuclear progressiva (PSP) és un parkinsonisme neurodegeneratiu caracteritzat patològicament pel dipòsit neuronal i glial de la proteïna tau de 4 repeticions (4R-tau) a diferència de la malaltia de ...

Regulation of lipid and redox metabolism in X-linked Adrenoleukodystrophy (X-ALD): therapeutic implications

Goicoechea Barrenechea, Leire (Date of defense: 2021-06-16)

X-linked adrenoleukodystrophy (X-ALD) is a rare neurometabolic disease characterized by the loss of function of the peroxisomal transporter ABCD1, which leads to an accumulation of very long-chain fatty acids (VLCFA), ...

Relación entre enfermedad de Parkinson y metabolismo de la glucosa: Estudio clínico de asociaciones bioquímicas y análisis epidemiológico de riesgo

Sánchez Gómez, Almudena (Date of defense: 2022-05-19)

[spa] Se considera que puede existir un vínculo entre la diabetes mellitus tipo 2 (DM2) y la enfermedad de Parkinson (EP) sustentado en la presencia de vías fisiopatológicas comunes en ambas entidades. No obstante, los ...

Resonancia magnética craneal estructural de 3 Tesla como biomarcador de neurodegeneración y pronóstico en la enfermedad de Alzheimer de inicio precoz

Contador Muñana, José Miguel (Date of defense: 2022-10-05)

[spa] Según la edad de inicio, la enfermedad de Alzheimer (EA) puede clasificarse en EA de inicio precoz (EAIP, menores de 65 años) o EA de inicio tardío (EAIT, mayores de 65 años). Ambas presentaciones comparten el sustrato ...

Rol de las proteínas α- y γ-sinucleína en la neurotransmisión dopaminérgica nigroestriatal y mesocortical: Implicación en enfermedades neurodegenerativas y trastornos neuropsiquiátricos

Pavia Collado, Rubén (Date of defense: 2020-11-06)

[spa] Las sinucleínas son una familia de proteínas pequeñas y altamente conservadas en vertebrados, especialmente abundantes en las neuronas y típicamente enriquecidas en los terminales presinápticos, donde participan en ...

Sleep-Disordered Breathing in Children with Cleft Palate

Moraleda Cibrián, Marta (Date of defense: 2022-07-11)

[eng] INTRODUCTION: One in 700 newborns in the United States is born with cleft palate every year. It is estimated that the prevalence of sleep-disordered breathing symptoms in children with cleft palate, compared with ...

Spatial learning in the network of hippocampal place cells: Altering memory using a mouse model of passive transfer of antibodies from patients with anti-NMDAR encephalitis

Zamani Mozafarabadi, AmirPasha (Date of defense: 2022-12-16)

[eng] Anti-NMDAR encephalitis is the most frequent antibody-mediated encephalitis known to date, in which patients develop specific antibodies directed against the N-methyl-D-aspartate receptors (NMDARs) in the central ...

Spatiotemporal dynamics of the cerebral cortex: from unconscious brain states towards consciousness

Camassa, Alessandra (Date of defense: 2021-07-23)

Understanding the dynamics of the brain that gives rise to conscious experience and that underscore the transition through different brain states is one of the central problems of today’s neuroscience. The cerebral cortex ...

Synaptic and circuit mechanisms of working memory and their dysfunction in anti-NMDA receptor encephalitis and schizophrenia

Stein, Heike (Date of defense: 2020-11-13)

[eng] In this thesis, I investigate different synaptic and circuit mechanisms of working memory, how their interaction produces specific working memory biases, and how their disruption in psychiatric or neurological disease ...

El Trastorno Bipolar en Edad Avanzada: un análisis neuropsicológico, clínico y de funcionamiento psicosocial

Montejo Egido, Laura (Date of defense: 2022-06-23)

[spa] Introducción: El trastorno bipolar (TB) es una enfermedad mental crónica y recurrente caracterizada por alteraciones en el estado de ánimo alternándose episodios depresivos con episodios de (hipo)manía y con periodos ...

Unraveling potential disease modifiers of myotonic dystrophy type 1

Koehorst, Emma Agathe (Date of defense: 2022-06-17)

[spa] La distrofia miotónica tipo 1 (DM1) es un trastorno multisistémico, progresivo y no tratable con una expansión CTG en el gen DMPK que es la base de la patología. La compleja naturaleza multisistémica de la DM1 ...

Utilitat dels models matemàtics amb neuroimatge pel diagnòstic i l'estudi de la variabilitat en la malaltia d'Alzheimer i la demència frontotemporal

Pérez Millan, Agnès (Date of defense: 2023-12-14)

[cat] La tesi titulada "Utilitat dels models matemàtics amb neuroimatge pel diagnòstic i l'estudi de la variabilitat en la malaltia d'Alzheimer i la demència frontotemporal" explora la utilitat de diferents models ...