Escobedo Pascual, Albert (Date of defense: 2014-11-06)
Nedd4L is a HECT-type E3 ubiquitin ligase (it covalently binds ubiquitin molecules before transferring them to the final substrate). Ubiquitination is a posttranslational modification (PTM) that labels ...
Ramírez Cota, Rosa María (Date of defense: 2016-07-05)
The depletion of MZT1 in human cells causes severe mitotic spindle defects. Depleted cells lack centrosomal γ-tubulin and arrest in mitosis with a monopolar spindle configuration. Similarly, double ...
Avó Freixo, Francisco Duque Projecto (Date of defense: 2016-10-20)
The microtubule cytoskeleton plays essential roles during cell division, migration, differentiation, defining cell morphology and organizing intracellular transport. The properties of microtubules, such ...
Herrera Camacho, Antonio (Date of defense: 2015-11-06)
El meduloblastoma es un tumor cerebral maligno localizado en la fosa posterior del cráneo, con una muy alta incidencia en niños. Hasta cuatro distintos subgrupos de meduloblastomas pueden ser definidos ...
Nieves Calatrava, Ingrid (Date of defense: 2015-11-24)
One of the ultimate goals in biomedicine is to understand the relationship between structure, function, and dynamics of biomolecules in living cells. The biophysical tools designed to gain more insight ...
Guillén Boixet, Jordina (Date of defense: 2015-12-04)
Cytoplasmic polyadenylation element binding proteins (CPEBs) are a family of RNA-binding proteins essential for the translational regulation of mRNAs in various biological contexts. CPEBs recognize CPE ...
Matalonga Borrel, Lesley (Date of defense: 2016-04-15)
Los trastornos lisosomales y la aciduria glutárica tipo I son las enfermedades objeto de este estudio. Dichas enfermedades, pertenecen al numeroso grupo de enfermedades metabólicas hereditarias (EMH) y ...
Chakraborty, Arka (Date of defense: 2016-07-08)
Mitochondria are intracellular double-membrane bound organelles in eukaryotic cells that act as the major suppliers of adenosine triphosphate (ATP). They possess their own DNA (mtDNA) that codes for ...
Iglesias Fernández, Javier (Date of defense: 2014-09-19)
Carbohydrates play a central role in transport and storage of energy and as molecular building blocks. Additionally, glycoconjugates, specifically glycoproteins and glycolipids, are important components ...
Campos Gorgona, Nefertiti (Date of defense: 2013-10-15)
En esta tesis se describen los resultados obtenidos en la clonación y caracterización de una nueva transglutaminasa (TGasa) vegetal aislada en arroz (Oryza sativa), la segunda transglutaminasa clonada ...