Castellá Giner, Moisés (Date of defense: 2023-09-29)
[emg] Alternative splicing (AS) is a gene expression regulatory mechanism that enables generation of multiple mRNA isoforms from a single gene which commonly are translated into proteins. This mechanism ...
Rossell Rusiñol, Joana (Date of defense: 2021-02-26)
An unbalanced, unhealthy diet is one of the main causes leading to obesity and the apparition of comorbidities. Bariatric surgery is currently the most effective and durable treatment against obesity. ...
Delgado Anglés, Alejandro (Date of defense: 2021-10-25)
Brown and beige adipose tissues are mediators of adaptive energy expenditure in mammals, in contrast with the energy storage role of white fat. Mitochondrial activity, including uncoupled respiration, ...
Gallego Pérez, Diego (Date of defense: 2022-09-29)
Molecular dynamics (MD) simulations are the equivalent to a computational microscope allowing us to interrogate molecules and their behaviour in complex systems. They are recognised as a valuable and ...
Quesada López, Tania Paloma (Date of defense: 2018-07-09)
Obesity prevalence has tripled in the last fifty years. For this reason, it is considered the pandemic of the century. It is characterized by the accumulation of metabolic abnormalities triggered by an ...
Torrent Juan, Roger (Date of defense: 2016-06-02)
Parkinson’s disease (PD) is an incurable neurodegenerative disorder, mainly characterized by a progressive loss of midbrain dopaminergic (DA) neurons, located in the substantia nigra pars compacta (SNpc), ...
Frager, Petra (Date of defense: 2022-10-28)
[eng] Decreased physical activity and increased consumption of energy-rich food are hallmark lifestyle modifications that developed and amplified over the course of only a few decades. These changes in ...
Núñez Carpintero, Iker (Date of defense: 2023-11-14)
[eng] The vast and continuously increasing volume of available biomedical data produced during the last decades opens new opportunities for large-scale modeling of disease biology, facilitating a more ...
Estadella Pérez, Irene (Date of defense: 2023-01-20)
[eng] The voltage gated potassium channel Kv1.3 is a transmembrane protein that selectively drives potassium ions participating in the electrochemical gradient of cell membranes. This channel presents ...
Cassinelli, Silvia (Date of defense: 2023-12-15)
[eng] The Kv1.3 voltage-dependent potassium channel plays a crucial role in the immune response participating in various cellular functions like proliferation, activation, and apoptosis. The aberrant ...