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From bee venom to blood-brain barrier shuttles. Development of minimized apamin derivatives for brain delivery of antibodies and other cargoes
Brain delivery is a major unmet challenge because most drugs cannot cross the blood-brain barrier (BBB). Despite the restrictive nature of this barrier, brain vasculature reaches essentially every neural cell to supply it ...
From Being NICE to Being Tired: Essays in Health Economics
This document is a summary of the first steps of my journey into academic research. The dissertation provides in-depth analysis of the theoretical basis of the British National Institute for Clinical Excellence (NICE) ...
From bond to attachment of the internationally adopted adolescent
Aquest treball avalua, en primer lloc, la importància del temps que els pares passen amb els fills adoptats entre l'arribada i l'escolarització i com això afecta a l'ajustament psicològic del menor. En segon lloc, valora ...
From burnout to engagement at work: Multi-sample empirical results in healthcare professionals
El burnout es un tema de interés desde hace 35 años (desde 1974), desde entonces se han desarrollado medidas, modelos teóricos, e investigaciones de muchos países han contribuido a una mejor comprensión de las causas y ...
From cells to tissues, microscopy to modeling: towards precise, data-driven photothermal therapy with gold nanorods
Suspensions of gold nanorods (GNRs) are emerging as potential drugs to address some of the limitations in traditional biomedical sensing,imaging and therapy. They are inorganic nanoparticles with good biocompatibility, ...
From characterization strategies to PDK & EDA Tools for Printed Electronics
Durant els últims anys, les tecnologies d’electrònica impresa (PE) estan atraient molta atenció, principalment degut a que es poden fabricar grans àrees, i són una alternativa de baix cost a la microelectrònica tradicional. ...
From chronic obstructive pulmonary disease to lung cancer : an immunologic approach
Se ha establecido que un subconjunto de pacientes con cáncer debuta con infiltrados inmunes que se organizan en agregados en el nicho tumoral y sus alrededores. Estas estructuras linfoides se desarrollan en respuesta ...
From circulating tumour cells to metastases: The role of Cyclin D1 and characterisation of new biomarkers
La metàstasi és un procés molt complex que està regulat per un elevat nombre de variables i senyalitzacions, entre altres la composició del microambient tumoral. Els objectius d'aquesta tesi són estudiar el paper de la ...
From Click Chemistry to catalytic cleavage of unstrained C-C bonds
Aquesta tesi doctoral es basa principalment amb la síntesis de molècules petites potencialment útils per investigacions avançades. S'han utilitzat diferents metodologies per obtenir-les: 1) Cicloaddicions intramoleculars ...
From cluster databases to cloud storage: Providing transactional support on the cloud
Durant les últimes tres dècades, les limitacions tecnològiques (com per exemple la capacitat dels dispositius d'emmagatzematge o l'ample de banda de les xarxes de comunicació) i les creixents demandes dels usuaris (estructures ...
From community structure to the physics of multiplex networks
Els sistemes complexes són sistemes que estan formats per un gran nombre d'unitats individuals, les quals interactuen entre elles, generalment de manera no-lineal, donant lloc a xarxes complexes d'interaccions. Sistemes ...
From Compression of Wearable-based Data to Effortless Indoor Positoning
The dissertation focuses on boosting the energy efficiency of IoT and wearable devices by implementing lossy compression techniques onto sensor-based time-series data and into indoor localization paradigms. The thesis deals ...
From corpora amylacea to wasteosomes
Corpora amylacea (CA) in the human brain are polyglucosan aggregates that were first described by J.E. Purkinje in 1837. They are intracellular astrocytic bodies that accumulate mainly in perivascular, periventricular and ...
From Dynamics to Structure of Complex Networks: Exploiting Heterogeneity in the Sakaguchi-Kuramoto Model
Most of the real-world complex systems are best described as complex networks and can be mathematically described as oscillatory systems, coupled with the neighbours through the connections of the network. The flashing of ...
From early life stress to adult psychopathology: An epigenetic view from monozygotic twin based approaches
Psychiatric disorders are highly prevalent and one of the leading causes of disease burden worldwide. Nevertheless, there are no validated biomarkers to be used for either diagnostic or prognostic purposes and their etiology ...
From energy saving technologies to green product innovation: evidence from the European Manufacturing Survey
Green manufacturers and an understanding of their differentiating characteristics and environmental and economic performance when applying green practices are at the centre of this doctoral thesis. The focus is set around ...
From flood to drought: Transport and reactivity of dissolved organic matter along a Mediterranean river
Rivers play a key role in the global biogeochemical functioning, as they link the biogeochemical cycles of the terrestrial and oceanic systems. In the framework of the carbon cycle, streams and rivers receive dissolved ...
From gathering to farming in semi-arid Northern Gujarat (India): a multi-proxy approach
Understanding how human societies adapted to past environmental and climatic variability is fundamental to face present and future climatic events, particularly in highly vulnerable arid and semi-arid regions. Northern ...
From global to local behind the relationship between the economy and the environment
El objetivo general del presente trabajo es analizar la relación entre la economía y el ambiente a diferentes escalas. Esto ha de ser comprendido como la elección de un problema de investigación en cada dimensión, y aplicar ...
From gold to carbon: How narratives and discourses define environmental governance in the Brazilian Amazon
El context global actual del canvi climàtic imposa grans reptes per a la gestió dels sistemes socials i ecològics. En aquest context, la regió amazònica al Brasil no només és un ‘punt calent’ per a la conservació de ...
