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Now showing items 35638-35657 of 41815
Role of the kidney androgen-regulated protein in the development of the metabolic syndrome
El síndrome metabólico (SM) incluye síntomas tales como la obesidad, la resistencia a la insulina, hiperinsulinemia compensatoria, dislipidemia (DLP) y la hipertensión arterial (HTA) en conjunto que lleva a la diabetes ...
Role of the Kinases NEK6, NEK7 and NEK9 in the Regulation of the Centrosome Cycle
This thesis project is focused on the study of the signaling module formed by the NIMA-related protein Nek6, Nek7, and Nek9 and their function during early mitosis, with particular interest in centrosome separation and ...
Role of the LILRB1 HLA class I-specific inhibitory receptor in the regulation of macrophage function
In the present work the regulatory role played by the HLA class I (HLA-I)-specific LILRB1 inhibitory receptor in human macrophages (MΦ) was addressed. In vitro differentiated monocyte-derived M1 and M2 MΦ expressed different ...
The Role of the Local Community Participation in the Management of Cultural Heritage: A Case Study of Rijal Almaa and Historical Example in Rural Saudi Arabia
Amb l’ampli enfocament en l’àmbit del patrimoni cultural a l’Aràbia Saudita durant les últimes dècades, també hi ha hagut un desenvolupament accelerat des del punt de vista institucional i acadèmic. Atès que la gestió del ...
Role of the MAP kinase Sty1 and the transcription factor Atf1 in euchromatin and heterochromatin dynamics in Schizosaccharomyces pombe
Eukaryotic DNA is condensed inside the nucleus, compacted into chromatin. The structure of chromatin is dynamic, and its accessibility to cellular machinery can be altered depending on the level of chromatin compaction ...
Role of the metacaspase AtMC1 in stress-triggered protein aggregate formation in yeast and plants
L’agregació de proteïnes és un fenomen generalitzat a les cèl·lules que es pot associar a condicions patològiques. La formació d’agregats de proteïnes és induïda per múltiples tipus d’estrès, inclosos temperatura, químic, ...
Role of the NADPH oxidase NOX4 in hepatocyte proliferation
[spa] La familia de las NADPH oxidasas ha emergido en los últimos años como una importante fuente de producción de radicales libres de oxígeno (ROS), los cuáles juegan un papel fundamental en situaciones fisiológicas y ...
Role of the NADPH Oxidase NOX4 in Liver Fibrosis and Hepatocarcinogenesis
Reactive oxygen species (ROS) are short-lived, highly electrophilic molecules generated by the partial reduction of oxygen to form superoxide, hydrogen peroxide and hydroxyl radical as well as other secondary metabolites. ...
The role of the oncogene prostate tumor overexpressed-1 and the regulation of mRNA translation in prostate cancer progression and chemoresistance
El cáncer de próstata (CaP) metastásico es actualmente incurable. Prostate tumor overexpressed 1 (PTOV1) se expresa a niveles altos en CaP y otras neoplasias asociado a estadíos más agresivos y mal pronóstico clínico. Un ...
Role of the protein quality control system in basal and stress conditions in fission yeast
Proteostasis is the proper homeostasis of the concentration and the molecular structure of the proteins, which preserves the integrity of the proteome. Proteo-stasis is constantly challenged by intrinsic and extrinsic ...
Role of the RecA protein in the structuration and function of Salmonella enterica chemotaxis signalling complexes
Salmonella enterica és un patogen entèric primari que infecta tant humans com animals i és la causa més freqüent de malalties transmeses per aliments. S. enterica es pot propagar a les persones a través d'aliments contaminats ...
Role of the regulation of cell lipid composition and membrane structure in the antitumor effect of 2-hydroxyoleic acid
El ácido 2-hidroxioleico (2OHOA) es un fármaco antitumoral diseñado para regular la estructura y composición de los lípidos de membrana y la función de importantes proteínas de membrana. El objetivo principal de este trabajo ...
Role of the sigma-1 receptor in the pathophysiology of osteoarthritis pain
Osteoarthritis is the most common musculoskeletal disease worldwide, characterized by degradation of the articular cartilage, chronic joint pain and disability. Currently available treatments for osteoarthritis have limited ...
Role of the sigma-1 receptor in the sensory-discriminative and affective-motivational components of acute and chronic pain
The present Doctoral Thesis focuses on the study of the sigma-1 receptor (σ1R) in the field of pain. This research has been a part of the preclinical σ1R project focusing on drug discovery of σ1R ligands for the treatment ...
Role of the species climatic niche on the insect-host system under drought episodes
En les darreres dècades, episodis climàtics extrems relacionats amb el canvi climàtic antropogènic han millorat la freqüència i magnitud de alteracions biòtiques, provocant la mortalitat mundial dels boscos. Particularment, ...
Role of the spleen in Plasmodium vivax: a reticulocyte-prone non-lethal malaria
“Plasmodium vivax” és el paràsit causant de malària humana amb més àmplia distribució i és responsable cada any de 100-300 milions de casos clinics, incloent algunes manifestacions severes i mort. P. vivax envaeix principalment ...
Role of the STAR proteins in early mammalian development and pluripotency
The molecular basis that sustain embryonic stem cell (ESCs) pluripotency and their differentiation in all the types of somatic cells is subject of intensive research. Recently, the potential involvement of RNA Binding ...
Role of the stress-dependent MAP kinase Sty1 and the transcription factor Atf1 in transcription regulation in fission yeast
In Schizosaccharomyces pombe, the MAPK pathway Sty1 is activated upon several stress situations, like osmotic and oxidative stress, stationary phase, UV radiation or heat shock. Since the modulation of gene expression is ...
Role of the Tousled like kinases in maintaining genome and epigenome stability
Histone deposition during DNA replication, transcription and repair ensures the faithful maintenance of genetic and epigenetic information. The histone H3-H4 chaperone ASF1 participates in both replication dependent and ...
Role of the transcription factor NFAT5 in mammalian cell cycle regulation
The transcription factor NFAT5/TonEBP belongs to the Rel family, which also comprises NF ÛB and NFATc proteins. NFAT5 only shares structural and functional homology with other Rel family members at the level of the DNA ...
