Now showing items 35638-35657 of 41897
Bellmunt i Tarragó, Anna (Date of defense: 2017-12-15)
The identification of genes that mediate metastasis is pivotal to better understand the mechanism, to develop novel drugs and to stratify patients with highest risk and consecutively administrate them preventive treatments. ...
Osuna Gómez, Rubén (Date of defense: 2020-07-23)
L’asma es una malaltia inflamatòria crònica que afecta aproximadament a 300 milions de persones en tot el mon. Aquesta malaltia es caracteritza principalment per un conjunt d’alteracions estructurals en les vies respiratòries, ...
Andreu Pérez, Pedro Antonio (Date of defense: 2012-03-12)
1. General Overview MTAP is a key enzyme in the methionine salvage pathway and controls the levels of methylthioadenosine (MTA). Lost of MTAP, which is frequent in melanoma, results in higher intra and extracellular MTA ...
Tur Torres, Juan (Date of defense: 2017-03-22)
Mitochondria are well known for their role as bioenergetic and biosynthetic organelles. Recently, they also have emerged as one of the main regulators of innate immune responses, mostly for its ability to modulate several ...
García Morales, Luis (Date of defense: 2015-11-20)
Mycoplasma genitalium és un patogen de transmissió sexual emergent. Aquest bacteri sense paret cel·lular causa uretritis, a més d’altres malalties inflamatòries genitals. Aquest microorganisme utilitza adhesines especialitzades ...
Suades Soler, Rosa (Date of defense: 2014-11-21)
Cardiovascular disease and, specifically, atherothrombosis is a global health problem with huge devastating consequences. While cardiovascular research has progressed rapidly over the last years, there is still a need ...
Baldrich, Patricia (Date of defense: 2015-10-22)
Los pequeños ARNs son ARNs cortos no codificantes que regulan la expresión génica en la mayoría de eucariotas. Las plantas tienen dos clases de pequeños ARNs, los microARNs (miRNAs) y los pequeños ARNs de interferencia ...
Vais, Ricardo Silva dos Santos (Date of defense: 2019-12-13)
The γ-‐tubulin ring complex (γTuRC) is required to efficiently generate new microtubules (MT) in a process known as MT nucleation. In mitotic cells, MT nucleation by γTuRC occurs from the centrosome, in vicinity of the ...
Peris Peris, Cristina (Date of defense: 2016-11-03)
Los microARNs (mirARNs) son un clase de pequeños ARNs no codificantes que actúan como reguladores de la expresión génica, y juegan un papel determinante en procesos fisiológicos de las plantas, en los que se incluyen ...
Muñoz San Martín, María (Date of defense: 2021-09-15)
Multiple sclerosis (MS) is considered a chronic inflammatory and neurodegenerative disease, characterized by the existence of demyelinated areas in the central nervous system, infiltration of inflammatory cells in the ...
Gentile, Maurizio (Date of defense: 2014-09-19)
The marginal zone (MZ) of the spleen contains an innate-like subset of B cells that mount rapid protective antibody responses to polysaccharides and lipids from bloodborne viruses and bacteria. These antigens activate ...
Pich Roselló, Oriol (Date of defense: 2021-03-24)
Cells of our body are constantly exposed to events that can create lesions in the DNA. If unremoved by the DNA repair mechanisms, the lesion may lead to a mutational event. Some of these events might drive the transformation ...
Macaya Erro, Irati (Date of defense: 2018-09-27)
La miosina VI (MYO6) es un motor molecular que puede anclar moléculas o proporcionar tráfico de corto alcance a lo largo del citoesqueleto de actina valiéndose de la energía obtenida de la hidrólisis de ATP. La miosina VI ...
Martel Duguech, Luciana M. (Date of defense: 2021-10-26)
El síndrome de Cushing (SC) i l’acromegàlia (ACRO) es presenten amb miopatia i debilitat muscular que persisteixen després de la remissió de l’excés d’hormones. La infiltració de greix intramuscular s’ha associat amb el ...
Güney, Emre (Date of defense: 2012-09-25)
The cell is governed by the complex interactions among various types of biomolecules. Coupled with environmental factors, variations in DNA can cause alterations in normal gene function and lead to a disease condition. ...
Kalafatoglu, Tugba (Date of defense: 2018-06-15)
L'emprenedoria es pot definir com "el procés mitjançant el qual les persones desco-breixen i exploten noves oportunitats de negocis, sovint mitjançant la creació de noves empreses" (Aldrich i Cliff, 2003: 575). Com a camp ...
Rodríguez Guillén, David (Date of defense: 2017-09-28)
La baja participación en las elecciones europeas, la crisis migratoria, el “Brexit”. A lo largo de los últimos años, la Unión Europea ha experimentado un creciente escepticismo. Aunque algunos argumentan que la crisis ...
Tellechea Recarte, Mónica (Date of defense: 2017-05-19)
Macrophages are exquisite sensors of tissue homeostasis that can rapidly switch between pro- and anti-inflammatory or regulatory modes to respond to perturbations in the microenvironment. This functional plasticity involves ...
Cabo, Mariona (Date of defense: 2019-11-08)
HER2 overexpression accounts for approximately 15-20% of breast tumors, and mainstay therapy for these patients includes HER2-specific antibodies in combination with chemotherapy. Although the efficacy of anti-HER2 antibodies ...
Robert Moreno, Alexandre (Date of defense: 2007-09-28)
The process that gives rise to all the mature blood cells from the HSCs (Hematopoietic Stem Cells) is known as hematopoiesis. In the adult, hematopoiesis takes place in the bone marrow although the HSCs are likely generated ...