Universitat Pompeu Fabra
Now showing items 2226-2245 of 3213
The activation of Notch1 receptor triggers differential outcomes depending on the upstream activating ligand. This way, Jag1-Notch1 activation promotes endothelial to hematopoietic transition process for the generation of ...
Wnt/β-catenin and Notch signalling cooperate in regulating the transcription of various genes specifically in the small intestinal stem and progenitor cell compartments. We characterized Bmi1 functionally in this context ...
Els tractaments actuals pel càncer de pàncreas presenten un eficàcia limitada de manera que es necessari el desenvolupament de noves teràpies antitumorals. La teràpia gènica pel càncer de pàncreas basada en l’ús d’adenovirus ...
Classical planning is the problem of finding a sequence of actions, from a given initial state to some goal state. While, in generalized planning, a plan is a solution to a set of planning problems, which belong to the ...
Autoinflammatory diseases are caused by an antigen independent hyperactivation of inflammatory pathways. The first genetic defect linked to an autoinflammatory disease was described almost 25 years ago and, since then, the ...
Cigarette smoking continues to be leading cause of preventable cause of death worldwide. Cognitive modulation by nicotine seems to be a key factor in nicotine addiction. Several studies indicate that initial nicotine intake ...
En la levadura S. cerevisiae, un incremento de la osmolaridad extracelular activa la vía de Hog1, lo que produce una compleja respuesta adaptativa. Entre las respuestas adaptativas que Hog1 coordina, está un importante ...
El continuo aumento de los proyectos de producción de datos genómicos a gran escala, como el "Earth BioGenome Project" (Lewin et al., 2018), pone los métodos de análisis de datos bajo una presión sin precedentes. Es necesario ...
Intellectual disability is a term used to describe a group of neurodevelopmental disorders defined by deficits in cognitive and adaptive functioning with onset during the developmental period. Preclinical research suggest ...
High drug attrition rate during clinical and post market phases is one of the major factors contributing to the pharmaceutical industry productivity crisis. This problem is especially worrisome in the cancer field, where ...
Macrophages play crucial roles in the defense of the organism against a wide range of pathogens. Macrophages can rapidly adapt to perturbations in the microenvironment due to the existence of a network of transcription ...
Chromocenters are established after the 2-cell (2C) stage during mouse embryonic development, but the factors that mediate chromocenter formation remain largely unknown. To identify regulators of 2C heterochromatin ...
Living organisms must respond to changes in their environment in order to overcome stress situations. In Schizosaccharomyces pombe, Sty1 MAP kinase is required to survive to a wide range of environmental stresses. The main ...
The view on how protein kinases regulate gene expression have recently expanded to include not only transcription factors but also histones, chromatin remodelers or components of the basal transcription machinery, which ...
Genome-wide analysis of the nucleosome positioning and histone H1 isoform content of the T47D breast cancer cell line has found a number of observations, namely that with a gentle digestion of microccocal nuclease (MNase), ...
El objeto de estudio de esta investigación es formular los fundamentos teóricos y metodológicos de un ordenamiento morfológico para el establecimiento de una Nueva Nomenclatura (NN) del futuro Diccionario de uso del quechua ...
La posibilidad estatal de almacenar información genética plantea importantes retos para las ciencias penales, pues las Bases de Datos de ADN agudizan la tensión entre los principios de libertad, seguridad e igualdad. ...
There are two main subjects in this thesis: the first one deals with the numerical simulation of shallow water equations, the other one is the resolution of some problems in image processing<br/><br/>The first part of this ...
El Código penal español reconoce desde 2010 la responsabilidad penal de las personas jurídicas, aunque limitada a un catálogo cerrado de delitos. La configuración del sistema de numerus clausus -como sucede con la práctica ...
The general aim of the thesis was to assess the role of nutritional factors in asthma in the French E3N study. The first objective was to compare principal component (PCA) with confirmatory factor analysis (CFA) to identify ...
