Hartasánchez Frenk, Diego Andrés (Date of defense: 2016-11-22)
Les regions duplicades del genoma, com ara les duplicacions de segments (SDs), són una característica comuna dels genomes eucariotes i han estat associades a canvis fenotípics. Donada la seva rellevància ...
Brasó-Vives, Marina (Date of defense: 2019-01-18)
La duplicació és el principal mecanisme de formació de nou material genètic i d'innovació funcional. Entendre com les duplicacions sorgeixen, evolucionen, co-evolucionen i engendren noves funcions és ...
Martínez Marigorta, Urko (Date of defense: 2012-11-12)
The aetiology of common diseases is shaped by the effects of genetic and environmental factors. Big efforts have been devoted to unravel the genetic basis of disease with the hope that it will help to ...
Farré Ramon, Xavier (Date of defense: 2022-07-01)
Ageing is a very complex phenotype that has been widely studied, but is still largely unknown. Most of the studies focus on a single species, or on performing genome wide association studies in human ...
Morcillo Suárez, Carlos (Date of defense: 2011-12-19)
New approaches are needed to manage and analyze the enormous quantity of biological data generated by modern technologies. Existing solutions are often fragmented and uncoordinated and, thus, they require ...
Rambla, Jordi (Date of defense: 2023-05-18)
The advance of precision medicine depends on the availability of data that is continuously being generated in universities, research centres and hospitals world-wide. That data represents 1) the diversity ...
Lorente Galdós, Maria Belén (Date of defense: 2011-11-11)
Identification of signatures of positive selection has long been a major issue for understanding the unique features of any given species. However, only a fraction of human genes have been interrogated. ...
Marquès i Bonet, Tomàs (Date of defense: 2007-01-15)
The main objectives of this work are:<br/>a) To test the predictions of suppressed-recombination chromosomal speciation models on two different lineages of mammals: rodents and rimates. Suppressed-recombination ...
Heredia Genestar, José María (Date of defense: 2020-01-28)
La mutació és un procés essencial per l’evolució, tot i que també té un rol important tant en el càncer com en altres malalties. Les mutacions no s’acumulen uniformement al llarg del genoma i la seva ...
Telford, Marco (Date of defense: 2017-12-19)
This thesis focuses on Human herpesvirus 4 and 6, two ubiquitous viruses with a long list of putative disease associations, ranging from malignancies such as lymphomas and carcinomas to multiple sclerosis. ...