Tilgner, Hagen (Date of defense: 2011-06-02)
L’Splicing de les molècules d’ARN és el procés pel qual les seqüències interposades (“introns”) s’eliminen, i les seqüències restants es concatenen per a formar l’ARN madur. La investigació recent ...
Borsari, Beatrice (Date of defense: 2021-03-26)
We have monitored the transcriptome and the epigenome of human pre-B cells transdifferentiating into macrophages. Analysis of these data provides a general framework to understand the relationship between ...
Breschi, Alessandra (Date of defense: 2016-11-28)
Mice are the premier model organisms to study human biology and disease, but there is still debate about the extent to which molecular mechanisms are conserved between human and mouse. With the advance ...
Bogu, Gireesh K. (Date of defense: 2017-01-13)
Widespread transcription in mammals revealed unexpected discovery of non-coding elements like long noncoding RNAs (lncRNAs) and repetitive elements. First, lncRNAs were previously identified in limited ...
Garrido Martín, Diego (Date of defense: 2020-01-30)
We have developed an efficient and reproducible pipeline for the identification of genetic variants affecting splicing (splicing quantitative trait loci or sQTLs), based on an approach that captures the ...