Neural efficiency of a specific cognitive training in working memory in multiple sclerosis patients

dc.contributor
Universitat Jaume I. Escola de Doctorat
dc.contributor.author
Aguirre Vidal, Naiara
dc.date.accessioned
2021-12-22T13:43:27Z
dc.date.available
2021-12-22T13:43:27Z
dc.date.issued
2021-12-13
dc.identifier.uri
http://hdl.handle.net/10803/673033
dc.description
Compendi d'articles, Doctorat internacional
dc.description
Doctorat internacional
dc.description.abstract
Multiple sclerosis is an autoimmune degenerative disease that produces cognitive impairment secondary to white and gray matter disruption of the central nervous system. The main objectives of this doctoral thesis were: First, to study spontaneous brain neuroplasticity processes associated with white matter lesions. Second, to study neuroplasticity processes induced after intensive working memory training. Regarding spontaneous neuroplasticity results, it was observed that white matter lesions located in the internal capsule are predominant in MS patients and cause functional connectivity changes that correlate negatively with cognitive performance. On the other hand, induced neuroplasticity results showed that a specific training in working memory produces similar neuroplasticity in patients as in healthy subjects. These changes in brain plasticity are also associated with cognitive performance improvement. These results can be interpreted as an increase in cognitive efficiency.
dc.format.extent
148 p.
dc.format.mimetype
application/pdf
dc.language.iso
eng
dc.publisher
Universitat Jaume I
dc.rights.license
L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-sa/4.0/
dc.rights.uri
http://creativecommons.org/licenses/by-sa/4.0/
*
dc.source
TDX (Tesis Doctorals en Xarxa)
dc.subject
Multiple sclerosis
dc.subject
Neuroplasticity
dc.subject
Working memory
dc.subject
Cognitive training
dc.subject
Connectivity
dc.subject
Magnetic resonance
dc.subject.other
Salut i serveis socials
dc.title
Neural efficiency of a specific cognitive training in working memory in multiple sclerosis patients
dc.type
info:eu-repo/semantics/doctoralThesis
dc.type
info:eu-repo/semantics/publishedVersion
dc.subject.udc
159.9
dc.contributor.director
Forn Frías, Cristina
dc.contributor.director
Ávila Rivera, César
dc.embargo.terms
cap
dc.rights.accessLevel
info:eu-repo/semantics/openAccess
dc.identifier.doi
http://dx.doi.org/10.6035/14109.2021.447259
dc.description.degree
Programa de Doctorat en Psicologia


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