Neural efficiency of a specific cognitive training in working memory in multiple sclerosis patients

Autor/a

Aguirre Vidal, Naiara

Director/a

Forn Frías, Cristina

Ávila Rivera, César

Fecha de defensa

2021-12-13

Páginas

148 p.



Departamento/Instituto

Universitat Jaume I. Escola de Doctorat

Programa de doctorado

Programa de Doctorat en Psicologia

Resumen

Multiple sclerosis is an autoimmune degenerative disease that produces cognitive impairment secondary to white and gray matter disruption of the central nervous system. The main objectives of this doctoral thesis were: First, to study spontaneous brain neuroplasticity processes associated with white matter lesions. Second, to study neuroplasticity processes induced after intensive working memory training. Regarding spontaneous neuroplasticity results, it was observed that white matter lesions located in the internal capsule are predominant in MS patients and cause functional connectivity changes that correlate negatively with cognitive performance. On the other hand, induced neuroplasticity results showed that a specific training in working memory produces similar neuroplasticity in patients as in healthy subjects. These changes in brain plasticity are also associated with cognitive performance improvement. These results can be interpreted as an increase in cognitive efficiency.

Palabras clave

Multiple sclerosis; Neuroplasticity; Working memory; Cognitive training; Connectivity; Magnetic resonance

Materias

159.9 - Psicología

Área de conocimiento

Salut i serveis socials

Nota

Compendi d'articles, Doctorat internacional

Doctorat internacional

Documentos

2021_Tesis_Aguirre Vidal_Naiara.pdf

5.237Mb

 

Derechos

L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-sa/4.0/
L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-sa/4.0/

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