Cebrià i Costa, Joan Pau (Date of defense: 2017-06-29)
L’oxidació de la histona 3 en la lisina 4 (H3K4ox) per acció de la lysil oxidase-like 2 (LOXL2) genera una nova modificació de la H3 amb una funció desconeguda. En aquesta tesi, hem determinat tant en ...
Trussart, Marie (Date of defense: 2015-10-30)
Des de l’aparició de les tecnologies de seqüenciació d’alt rendiment, els conjunts de dades biològiques han esdevingut cada cop més grans i complexes, la qual cosa els fa pràcticament impossibles ...
Cuscó Pons, Pol (Date of defense: 2017-12-13)
Des de l’aparició de les tecnologies de seqüenciació d’alt rendiment, els conjunts de dades biològiques han esdevingut cada cop més grans i complexes, la qual cosa els fa pràcticament impossibles ...
Dumbović, Gabrijela (Date of defense: 2017-01-12)
DNA hypomethylation of repeats has been found in almost every tumor type studied. Hypomethylation of repetitive elements was shown to increase the likelihood of homologous recombination of these repeated ...
Reina García, Óscar (Date of defense: 2018-04-10)
We developed a computational framework implemented as an R package for generation, visualization and functional and differential analysis of epigenome maps. Methods are provided for integrating and ...
Mocavini, Ivano (Date of defense: 2022-03-31)
Polycomb repressive complex (PRC)1 and 2 are major players in gene regulation, devoted to maintenance of the epigenetic memory of gene silencing. Mouse embryonic stem cells (mESCs) have been extensively ...
Islam, Abul (Date of defense: 2012-06-25)
Recent advances in high throughput technology have opened the door to systematic studies of epigenetic mechanisms. One of the key components in the regulation of the cell cycle and differentiation is ...
Cantacorps Centellas, Lídia (Date of defense: 2019-11-15)
Maternal alcohol binge drinking during pregnancy can be deleterious for the developing foetus, leading to a wide range of long-lasting morphological and neurobehavioural disabilities known as foetal ...
Victor, Pedro Sousa (Date of defense: 2012-02-27)
Muscle aging, in particular, is characterized by the reduction of tissue mass and function, which are particularly prominent in geriatric individuals undergoing sarcopenia. The age-associated muscle ...
Díaz Blanco, Noelia (Date of defense: 2014-10-24)
In many gonochoristic fish, sex is plastic since it can be altered by the influence of environmental factors. In this thesis, using the European sea bass (Dicentrarchus labrax) model, a teleost fish ...